Berberine, kapena berberine hydrochloride, ndi mankhwala omwe amapezeka m'zomera zambiri. Angathandize kuchiza matenda monga matenda a shuga, cholesterol yambiri komanso kuthamanga kwa magazi. Komabe, zotsatirapo zake zingakhale monga kusokonezeka m'mimba ndi nseru.
Berberine yakhala mbali ya mankhwala achi China ndi Ayurvedic kwa zaka masauzande ambiri. Imagwira ntchito m'thupi m'njira zosiyanasiyana ndipo imatha kuyambitsa kusintha mkati mwa maselo a thupi.
Kafukufuku wasonyeza kuti berberine imatha kuchiza matenda osiyanasiyana a kagayidwe kachakudya m'thupi, kuphatikizapo matenda a shuga, kunenepa kwambiri, ndi matenda a mtima. Ingathandizenso thanzi la m'mimba.
Ngakhale kuti berberine ikuwoneka kuti ndi yotetezeka ndipo ili ndi zotsatirapo zochepa, muyenera kufunsa dokotala musanamwe.
Berberine ikhoza kukhala mankhwala othandiza polimbana ndi mabakiteriya. Kafukufuku wa 2022 adapeza kuti berberine imathandiza kuletsa kukula kwa Staphylococcus aureus.
Kafukufuku wina adapeza kuti berberine imatha kuwononga DNA ndi mapuloteni a mabakiteriya ena.
Kafukufuku akuwonetsa kuti berberine ili ndi mphamvu zotsutsana ndi kutupa, zomwe zikutanthauza kuti ingathandize kuchiza matenda a shuga ndi matenda ena okhudzana ndi kutupa.
Kafukufuku akusonyeza kuti berberine ingakhale yothandiza pochiza matenda a shuga. Kafukufuku wasonyeza kuti ingathandize pa:
Kusanthula komweko kunapeza kuti kuphatikiza kwa berberine ndi mankhwala ochepetsa shuga m'magazi kunali kothandiza kwambiri kuposa mankhwala onsewa okha.
Malinga ndi kafukufuku wa 2014, berberine ikuwonetsa chiyembekezo ngati chithandizo cha matenda ashuga, makamaka kwa anthu omwe sangathe kumwa mankhwala omwe alipo kale chifukwa cha matenda a mtima, kulephera kwa chiwindi, kapena mavuto a impso.
Kuwunikanso kwina kwa mabukuwa kunapeza kuti berberine pamodzi ndi kusintha kwa moyo wa munthu kunachepetsa shuga m'magazi kuposa kusintha kwa moyo wa munthu kokha.
Zikuoneka kuti Berberine imayambitsa puloteni kinase yomwe imayambitsa AMP, yomwe imathandiza kuwongolera momwe thupi limagwiritsira ntchito shuga m'magazi. Ofufuza amakhulupirira kuti kuyambitsa kumeneku kungathandize kuchiza matenda a shuga ndi mavuto ena azaumoyo monga kunenepa kwambiri komanso cholesterol yambiri.
Kusanthula kwina kwa 2020 kunawonetsa kusintha kwa kulemera kwa thupi ndi magawo a kagayidwe kachakudya popanda kuwonjezeka kwakukulu kwa ntchito ya ma enzyme a chiwindi.
Komabe, asayansi ayenera kuchita maphunziro akuluakulu, osawona kawiri kuti adziwe bwino chitetezo ndi mphamvu ya berberine.
Lankhulani ndi dokotala wanu musanamwe berberine ya matenda ashuga. Mwina si yoyenera aliyense ndipo ingagwirizane ndi mankhwala ena.
Kuchuluka kwa cholesterol ndi LDL triglycerides kungapangitse kuti munthu adwale matenda a mtima komanso sitiroko.
Umboni wina umasonyeza kuti berberine ingathandize kuchepetsa cholesterol ya LDL ndi triglycerides. Malinga ndi ndemanga ina, kafukufuku wa nyama ndi anthu akuwonetsa kuti berberine imachepetsa cholesterol.
Izi zingathandize kuchepetsa LDL, cholesterol "yoyipa", ndikuwonjezera HDL, cholesterol "yabwino".
Kuwunikanso mabuku kunapeza kuti berberine pamodzi ndi kusintha kwa moyo kumathandiza kwambiri pochiza cholesterol yambiri kuposa kusintha kwa moyo kokha.
Ofufuza amakhulupirira kuti berberine ingachite chimodzimodzi ndi mankhwala ochepetsa cholesterol popanda kuyambitsa zotsatira zomwezo.
Kuwunikanso mabuku kunapeza kuti berberine inali yothandiza kwambiri kuphatikiza ndi mankhwala ochepetsa kuthamanga kwa magazi kuposa yokha.
Kuphatikiza apo, zotsatira za kafukufuku wa makoswe zikusonyeza kuti berberine ingachedwetse kuyamba kwa kuthamanga kwa magazi ndikuthandizira kuchepetsa kuopsa kwake kuthamanga kwa magazi kukachitika.
Ndemanga ina inanena za kuchepa thupi kwakukulu mwa anthu omwe amamwa mamiligalamu 750 (mg) a barberry kawiri patsiku kwa miyezi itatu. Barberry ndi chomera chokhala ndi berberine yambiri.
Kuphatikiza apo, kafukufuku wa anthu awiri osawona bwino adapeza kuti anthu omwe ali ndi vuto la metabolic syndrome omwe adamwa 200 mg ya barberry katatu patsiku anali ndi index yotsika ya body mass.
Gulu lomwe likuchita kafukufuku wina linanena kuti berberine ingayambitse minofu ya mafuta ofiirira. Minofu imeneyi imathandiza thupi kusintha chakudya kukhala kutentha kwa thupi, ndipo kuwonjezeka kwa mphamvu ya thupi kungathandize kuchiza kunenepa kwambiri ndi matenda a kagayidwe kachakudya.
Kafukufuku wina akusonyeza kuti berberine imagwira ntchito mofanana ndi mankhwala a metformin, omwe madokotala nthawi zambiri amapereka pochiza matenda a shuga a mtundu wa 2. Ndipotu, berberine ikhoza kukhala ndi mphamvu yosintha mabakiteriya m'matumbo, zomwe zingathandize kuchiza kunenepa kwambiri ndi matenda a shuga.
Matenda a Polycystic ovary syndrome (PCOS) amapezeka akazi akamakhala ndi mahomoni enaake aamuna ambiri. Matendawa ndi kusalinganika kwa mahomoni ndi kagayidwe kachakudya komwe kungayambitse kusabereka ndi mavuto ena azaumoyo.
Matenda a ovary a Polycystic amagwirizana ndi mavuto ambiri omwe berberine angathandize kuthetsa. Mwachitsanzo, anthu omwe ali ndi PCOS angakhalenso ndi:
Madokotala nthawi zina amalemba metformin, mankhwala a matenda ashuga, pochiza PCOS. Popeza berberine ili ndi zotsatira zofanana ndi metformin, ingakhalenso njira yabwino yothandizira PCOS.
Kuwunikanso mwadongosolo kunapeza kuti berberine ndi yothandiza pochiza matenda a ovary a polycystic omwe ali ndi insulin resistance. Komabe, olembawo akuti kutsimikizira izi kumafuna kafukufuku wowonjezereka.
Berberine ingayambitse kusintha kwa mamolekyulu a maselo, zomwe zingakhale ndi phindu lina: kulimbana ndi khansa.
Kafukufuku wina akusonyeza kuti berberine imathandiza kuchiza khansa mwa kuletsa kupita patsogolo kwake komanso moyo wake wamba. Ikhozanso kupha maselo a khansa.
Kutengera ndi deta iyi, olembawo akunena kuti berberine ndi mankhwala "othandiza kwambiri, otetezeka, komanso otsika mtengo" oletsa khansa.
Komabe, ndikofunikira kukumbukira kuti ofufuza adangophunzira za zotsatira za berberine pa maselo a khansa mu labotale osati mwa anthu.
Malinga ndi kafukufuku wina wofalitsidwa mu 2020, ngati berberine ingathandize kuchiza khansa, kutupa, matenda a shuga ndi matenda ena, mwina chifukwa cha zotsatira zake zabwino pa microbiome ya m'mimba. Asayansi apeza kulumikizana pakati pa microbiome ya m'mimba (magulu a mabakiteriya m'matumbo) ndi matenda awa.
Berberine ili ndi mphamvu zotsutsana ndi mabakiteriya ndipo imachotsa mabakiteriya owopsa m'matumbo, motero imalimbikitsa kukula kwa mabakiteriya athanzi.
Ngakhale kuti kafukufuku mwa anthu ndi makoswe akusonyeza kuti izi zitha kukhala zoona, asayansi akuchenjeza kuti kafukufuku wowonjezereka akufunika kuti atsimikizire momwe berberine imakhudzira anthu komanso ngati ndi yotetezeka kugwiritsa ntchito.
Bungwe la American Association of Naturopathic Physicians (AANP) limati ma berberine supplements amapezeka mu mawonekedwe a supplement kapena capsule.
Amawonjezera kuti maphunziro ambiri amalimbikitsa kumwa 900-1500 mg patsiku, koma anthu ambiri amamwa 500 mg katatu patsiku. Komabe, AANP imalimbikitsa anthu kuti akafunse dokotala asanamwe berberine kuti akaone ngati ndi yotetezeka kugwiritsa ntchito komanso mlingo womwe angatenge.
Ngati dokotala avomereza kuti berberine ndi yotetezeka kugwiritsa ntchito, anthu ayeneranso kuyang'ana chizindikiro cha mankhwalawo kuti apeze satifiketi ya chipani chachitatu, monga National Science Foundation (NSF) kapena NSF International, ikutero AANP.
Olemba kafukufuku wa 2018 adapeza kuti kuchuluka kwa makapisozi osiyanasiyana a berberine kumasiyana kwambiri, zomwe zingayambitse chisokonezo pankhani ya chitetezo ndi mlingo. Sanapeze kuti mtengo wokwera umasonyeza kuti mankhwalawo ndi abwino kwambiri.
Bungwe la US Food and Drug Administration (FDA) silikhazikitsa malamulo okhudza zakudya zowonjezera. Palibe chitsimikizo chakuti zowonjezerazo ndi zotetezeka kapena zogwira ntchito, ndipo nthawi zina sizingatheke kutsimikizira mtundu wa mankhwalawo.
Asayansi amati berberine ndi metformin ali ndi makhalidwe ambiri ndipo onsewa angakhale othandiza pochiza matenda a shuga amtundu wachiwiri.
Komabe, ngati dokotala apatsa munthu mankhwala a metformin, sayenera kuganizira za berberine ngati njira ina popanda kukambirana kaye ndi dokotala wawo.
Madokotala adzapereka mlingo woyenera wa metformin kwa munthu kutengera kafukufuku wazachipatala. N'zosatheka kudziwa momwe zowonjezerazo zimagwirizanirana ndi kuchuluka kumeneku.
Berberine ingagwirizane ndi metformin ndikukhudza shuga m'magazi mwanu, zomwe zimapangitsa kuti zikhale zovuta kuwongolera. Mu kafukufuku wina, kumwa berberine ndi metformin pamodzi kunachepetsa mphamvu ya metformin ndi 25%.
Berberine ikhoza kukhala njira ina yabwino yogwiritsira ntchito m'malo mwa metformin pochepetsa shuga m'magazi, koma kafukufuku wowonjezereka akufunika.
Bungwe la National Center for Complementary and Integrative Health (NCCIH) linanena kuti goldenrod, yomwe ili ndi berberine, siingayambitse mavuto aakulu pakapita nthawi ngati akuluakulu amwa. Komabe, palibe chidziwitso chokwanira chosonyeza kuti ndi yotetezeka kugwiritsidwa ntchito kwa nthawi yayitali.
Mu kafukufuku wa nyama, asayansi adazindikira zotsatira zotsatirazi kutengera mtundu wa nyama, kuchuluka kwake ndi nthawi yomwe yaperekedwa:
Ndikofunikira kulankhula ndi dokotala wanu musanamwe berberine kapena mankhwala ena owonjezera chifukwa sangakhale otetezeka ndipo sangakhale oyenera aliyense. Aliyense amene ali ndi vuto la ziwengo ndi mankhwala aliwonse azitsamba ayenera kusiya kugwiritsa ntchito nthawi yomweyo.