Berberine, kapena berberine hydrochloride, ndi mankhwala omwe amapezeka muzomera zambiri. Itha kuthandizira kuchiza matenda monga shuga, cholesterol yayikulu komanso kuthamanga kwa magazi. Komabe, zotsatira zake zingaphatikizepo kukhumudwa m'mimba ndi nseru.
Berberine wakhala mbali ya mankhwala achi China ndi Ayurvedic kwa zaka masauzande ambiri. Zimagwira ntchito m'thupi m'njira zosiyanasiyana ndipo zimatha kubweretsa kusintha m'maselo a thupi.
Kafukufuku wa berberine akuwonetsa kuti imatha kuchiza matenda osiyanasiyana a metabolic, kuphatikiza shuga, kunenepa kwambiri, ndi matenda amtima. Zingathenso kupititsa patsogolo thanzi la m'matumbo.
Ngakhale kuti berberine ikuwoneka ngati yotetezeka komanso imakhala ndi zotsatirapo zochepa, muyenera kufunsa dokotala musanamwe.
Berberine akhoza kukhala wothandizira antibacterial wothandizira. Kafukufuku wa 2022 adapeza kuti berberine imalepheretsa kukula kwa Staphylococcus aureus.
Kafukufuku wina anapeza kuti berberine ikhoza kuwononga DNA ndi mapuloteni a mabakiteriya ena.
Kafukufuku akuwonetsa kuti berberine ili ndi anti-inflammatory properties, kutanthauza kuti ingathandize kuchiza matenda a shuga ndi matenda ena okhudzana ndi kutupa.
Kafukufuku akuwonetsa kuti berberine ikhoza kukhala yothandiza pochiza matenda a shuga. Kafukufuku wasonyeza kuti ikhoza kukhala ndi zotsatira zabwino pa:
Kusanthula komweku kunapeza kuti kuphatikiza kwa berberine ndi mankhwala ochepetsa shuga m'magazi kunali kothandiza kwambiri kuposa mankhwala aliwonse okha.
Malinga ndi kafukufuku wa 2014, berberine ikuwonetsa lonjezo ngati chithandizo cha matenda a shuga, makamaka kwa anthu omwe sangathe kumwa mankhwala omwe alipo chifukwa cha matenda a mtima, kulephera kwa chiwindi, kapena mavuto a impso.
Kubwereza kwina kwa mabukuwa kunapeza kuti berberine pamodzi ndi kusintha kwa moyo kumachepetsa kuchuluka kwa shuga m'magazi kuposa kusintha kwa moyo kokha.
Berberine ikuwoneka kuti imayambitsa AMP-activated protein kinase, yomwe imathandiza kulamulira kagwiritsidwe ntchito ka shuga m'magazi. Ofufuza akukhulupirira kuti izi zitha kuthandiza kuchiza matenda a shuga komanso zovuta zokhudzana ndi thanzi monga kunenepa kwambiri komanso cholesterol yayikulu.
Kusanthula kwina kwa 2020 kunawonetsa kusintha kwa kulemera kwa thupi ndi magawo a metabolic popanda kuwonjezeka kwakukulu kwa ntchito ya enzyme ya chiwindi.
Komabe, asayansi ayenera kuchita kafukufuku wokulirapo, wosawona kawiri kuti adziwe bwino za chitetezo ndi mphamvu ya berberine.
Lankhulani ndi dokotala musanatenge berberine ya shuga. Zingakhale zosayenera kwa aliyense ndipo zikhoza kugwirizana ndi mankhwala ena.
Kuchuluka kwa cholesterol ndi low-density lipoprotein (LDL) triglycerides kungapangitse chiopsezo cha matenda a mtima ndi sitiroko.
Umboni wina umasonyeza kuti berberine ingathandize kuchepetsa LDL cholesterol ndi triglycerides. Malinga ndi ndemanga ina, kafukufuku wa nyama ndi anthu akuwonetsa kuti berberine amachepetsa cholesterol.
Izi zitha kuthandiza kuchepetsa LDL, cholesterol "yoyipa", ndikuwonjezera HDL, cholesterol "yabwino".
Kuwunika kwa zolembedwazo kunapeza kuti berberine kuphatikiza ndi kusintha kwa moyo kumakhala kothandiza kwambiri pochiza cholesterol yayikulu kuposa kusintha kwa moyo kokha.
Ofufuza amakhulupirira kuti berberine imatha kuchita chimodzimodzi ndi mankhwala ochepetsa mafuta m'thupi popanda kubweretsa zotsatirapo zomwezo.
Kuwunika kwa zolembedwazo kunapeza kuti berberine inali yothandiza kwambiri kuphatikiza ndi mankhwala ochepetsa kuthamanga kwa magazi kuposa yokha.
Kuonjezera apo, zotsatira za kafukufuku wa makoswe zimasonyeza kuti berberine ikhoza kuchedwetsa kuyamba kwa kuthamanga kwa magazi ndikuthandizira kuchepetsa kuopsa kwake pamene kuthamanga kwa magazi kumachitika.
Ndemanga imodzi inanena kuti kulemera kwakukulu kwa anthu omwe amamwa mamiligalamu 750 (mg) a barberry kawiri tsiku lililonse kwa miyezi itatu. Barberry ndi chomera chomwe chili ndi berberine yambiri.
Kuphatikiza apo, kafukufuku wosawona kawiri adapeza kuti anthu omwe ali ndi metabolic syndrome omwe amamwa 200 mg wa barberry katatu patsiku anali ndi index yotsika ya thupi.
Gulu lomwe likuchita kafukufuku wina lidazindikira kuti berberine imatha kuyambitsa minofu ya bulauni ya adipose. Minofu iyi imathandizira kuti thupi lisinthe chakudya kukhala kutentha kwa thupi, ndipo kupatsa mphamvu kwambiri kungathandize kuchiza kunenepa kwambiri komanso metabolic syndrome.
Kafukufuku wina akuwonetsa kuti berberine amagwira ntchito mofanana ndi metformin, yomwe madokotala nthawi zambiri amalembera kuti athetse matenda amtundu wa 2. M'malo mwake, berberine amatha kusintha mabakiteriya am'matumbo, omwe angathandize kuchiza kunenepa kwambiri komanso matenda a shuga.
Polycystic ovary syndrome (PCOS) imachitika pamene amayi ali ndi kuchuluka kwa mahomoni ena achimuna. Matendawa ndi kusalinganika kwa mahomoni komanso kagayidwe kachakudya komwe kungayambitse kusabereka komanso mavuto ena azaumoyo.
Polycystic ovary syndrome imalumikizidwa ndi mavuto ambiri omwe berberine angathandize kuthetsa. Mwachitsanzo, anthu omwe ali ndi PCOS angakhalenso ndi:
Nthawi zina madokotala amapereka metformin, mankhwala a shuga, kuti athetse PCOS. Popeza berberine ili ndi zotsatira zofanana ndi metformin, itha kukhalanso njira yabwino yothandizira PCOS.
Kuwunika mwadongosolo kunapeza berberine kukhala yodalirika pochiza matenda a polycystic ovary okhala ndi insulin kukana. Komabe, olembawo amawona kuti kutsimikiziridwa kwa zotsatirazi kumafuna kufufuza kwina.
Berberine ikhoza kuyambitsa kusintha kwa mamolekyu am'manja, omwe angakhale ndi phindu lina: kumenyana ndi khansa.
Kafukufuku wina akuwonetsa kuti berberine imathandiza kuchiza khansa poletsa kupita patsogolo kwake komanso kuzungulira kwa moyo. Zingathenso kupha maselo a khansa.
Kutengera izi, olembawo akunena kuti berberine ndi "mankhwala othandiza kwambiri, otetezeka, komanso otsika mtengo" oletsa khansa.
Komabe, ndikofunikira kukumbukira kuti ofufuza adangophunzira zotsatira za berberine pama cell a khansa mu labotale osati mwa anthu.
Malinga ndi kafukufuku wina wofalitsidwa mu 2020, ngati berberine ingathandize kuchiza khansa, kutupa, matenda a shuga ndi matenda ena, zikhoza kukhala chifukwa cha ubwino wake pa gut microbiome. Asayansi apeza kugwirizana pakati pa gut microbiome (magawo a mabakiteriya m'matumbo) ndi izi.
Berberine ali ndi antibacterial properties ndipo amachotsa mabakiteriya oipa m'matumbo, motero amalimbikitsa kukula kwa mabakiteriya athanzi.
Ngakhale kafukufuku wa anthu ndi makoswe akusonyeza kuti izi zikhoza kukhala zoona, asayansi akuchenjeza kuti kafukufuku wochuluka akufunika kuti atsimikizire momwe berberine imakhudzira anthu komanso ngati ndi yotetezeka kugwiritsa ntchito.
American Association of Naturopathic Physicians (AANP) imanena kuti zowonjezera za berberine zimapezeka muzowonjezera kapena mawonekedwe a capsule.
Amawonjezera kuti maphunziro ambiri amalimbikitsa kutenga 900-1500 mg patsiku, koma anthu ambiri amatenga 500 mg katatu patsiku. Komabe, AANP imalimbikitsa anthu kukaonana ndi dokotala asanamwe berberine kuti awone ngati ili yotetezeka kugwiritsira ntchito komanso mlingo wotani womwe ungamwe.
Ngati dokotala avomereza kuti berberine ndi yotetezeka kugwiritsa ntchito, anthu ayenera kuyang'ananso chizindikiro cha mankhwala kuti apeze chiphaso chachitatu, monga National Science Foundation (NSF) kapena NSF International, inatero AANP.
Olemba kafukufuku wa 2018 adapeza kuti zomwe zili m'makapisozi osiyanasiyana a berberine zimasiyana mosiyanasiyana, zomwe zitha kubweretsa chisokonezo pazachitetezo ndi mlingo. Sanapeze kuti mtengo wokwera umasonyeza khalidwe lapamwamba la mankhwala.
Bungwe la US Food and Drug Administration (FDA) silimawongolera zakudya zowonjezera zakudya. Palibe chitsimikizo chakuti zowonjezera ndizotetezeka kapena zothandiza, ndipo sizingatheke nthawi zonse kutsimikizira mtundu wa mankhwala.
Asayansi akuti berberine ndi metformin zimagawana mikhalidwe yambiri ndipo zonsezi zitha kukhala zothandiza pochiza matenda amtundu wa 2.
Komabe, ngati dokotala apereka metformin kwa munthu, sayenera kuona berberine ngati njira ina popanda kukambirana kaye ndi dokotala wawo.
Madokotala adzapereka mlingo woyenera wa metformin kwa munthu kutengera maphunziro azachipatala. Sizingatheke kudziwa momwe zowonjezera zowonjezera zimayenderana ndi ndalamazi.
Berberine imatha kuyanjana ndi metformin ndikukhudza shuga lanu lamagazi, zomwe zimapangitsa kuti zikhale zovuta kuwongolera. Mu kafukufuku wina, kutenga berberine ndi metformin pamodzi kunachepetsa zotsatira za metformin ndi 25%.
Berberine tsiku lina ikhoza kukhala njira yabwino yosinthira metformin yowongolera shuga m'magazi, koma kafukufuku wochulukirapo akufunika.
National Center for Complementary and Integrative Health (NCCIH) imanena kuti goldenrod, yomwe ili ndi berberine, sizingatheke kubweretsa zotsatira zoopsa pakapita nthawi ngati akuluakulu atenga pakamwa. Komabe, palibe chidziwitso chokwanira chowonetsa kuti ndi chotetezeka kuti chigwiritsidwe ntchito kwa nthawi yayitali.
M'maphunziro a nyama, asayansi adawona zotsatirazi kutengera mtundu wa nyama, kuchuluka kwake komanso nthawi yoyendetsera:
Ndikofunika kulankhula ndi dokotala musanamwe berberine kapena zowonjezera zina chifukwa sizingakhale zotetezeka ndipo sizingakhale zoyenera kwa aliyense. Aliyense amene ali ndi vuto ndi mankhwala azitsamba aliwonse ayenera kusiya kugwiritsa ntchito nthawi yomweyo.