Chowonjezera chotchedwa 5-hydroxytryptophan (5-HTP) kapena osetriptan imatengedwa kuti ndi imodzi mwa njira zothandizira mutu ndi migraines. Thupi limasintha mankhwalawa kukhala serotonin (5-HT), yomwe imadziwikanso kuti serotonin, neurotransmitter yomwe imayang'anira kusinthasintha komanso kupweteka.
Kuchepa kwa serotonin kumawoneka mwa anthu omwe ali ndi vuto la kuvutika maganizo, koma odwala mutu waching'alang'ala komanso odwala mutu amathanso kukhala ndi serotonin yotsika panthawi ndi pakati. Sizikudziwika chifukwa chake migraines ndi serotonin zimalumikizidwa. Mfundo yodziwika kwambiri ndi yakuti kusowa kwa serotonin kumapangitsa kuti anthu azimva kupweteka kwambiri.
Chifukwa cha kulumikizana kumeneku, njira zingapo zowonjezerera ntchito za serotonin muubongo zimagwiritsidwa ntchito poletsa mutu waching'alang'ala komanso kuchiza matenda oopsa.
5-HTP ndi amino acid yopangidwa ndi thupi kuchokera ku amino acid yofunika L-tryptophan ndipo iyenera kupezeka kuchokera ku chakudya. L-tryptophan imapezeka muzakudya monga mbewu, soya, Turkey ndi tchizi. Ma enzyme mwachilengedwe amasintha L-tryptophan kukhala 5-HTP, yomwe imatembenuza 5-HTP kukhala 5-HT.
Zowonjezera za 5-HTP zimapangidwa kuchokera ku chomera chamankhwala chaku West Africa Griffonia simplicifolia. Chowonjezera ichi chakhala chikugwiritsidwa ntchito pochiza kuvutika maganizo, fibromyalgia, matenda otopa kwambiri, komanso kuchepetsa thupi, koma palibe umboni wotsimikizirika wa ubwino wake.
Poganizira za 5-HTP kapena zowonjezera zilizonse zachilengedwe, ndikofunikira kumvetsetsa kuti mankhwalawa ndi mankhwala. Ngati muwatenga chifukwa ali ndi mphamvu zokwanira kuti akhale ndi zotsatira zabwino pa thanzi lanu, kumbukirani kuti angakhalenso amphamvu kuti akhale ndi zotsatira zoipa.
Sizikudziwika ngati zowonjezera za 5-HTP ndizopindulitsa kwa migraines kapena mitundu ina ya mutu. Ponseponse, kafukufuku ndi wochepa; Kafukufuku wina akuwonetsa kuti zimathandiza, pomwe ena samawonetsa zotsatira zake.
Maphunziro a Migraine agwiritsa ntchito Mlingo wa 5-HTP kuyambira 25 mpaka 200 mg patsiku mwa akulu. Pakalipano palibe mlingo womveka bwino kapena wovomerezeka wa zowonjezera izi, koma ndizofunika kudziwa kuti mlingo wapamwamba umagwirizanitsidwa ndi zotsatirapo ndi kuyanjana kwa mankhwala.
5-HTP ingagwirizane ndi mankhwala ena, kuphatikizapo carbidopa, omwe amagwiritsidwa ntchito pochiza matenda a Parkinson. Zitha kuyanjananso ndi triptans, SSRIs, ndi monoamine oxidase inhibitors (MAOIs, gulu lina la antidepressants).
Tryptophan ndi 5-HTP zowonjezera zikhoza kuipitsidwa ndi chilengedwe cha 4,5-tryptophanione, neurotoxin yomwe imatchedwanso Peak X. Zotsatira zotupa za Peak X zingayambitse kupweteka kwa minofu, kupweteka, ndi kutentha thupi. Zotsatira za nthawi yayitali zingaphatikizepo kuwonongeka kwa minofu ndi mitsempha.
Chifukwa chakuti mankhwalawa ndi opangidwa ndi mankhwala opangidwa ndi mankhwala osati zonyansa kapena zowonongeka, amatha kupezeka muzowonjezera ngakhale zitakonzedwa pansi pa ukhondo.
Ndikofunika kukambirana za kumwa mankhwala owonjezera ndi dokotala kapena wamankhwala kuti muwonetsetse kuti ali otetezeka kwa inu ndipo sangagwirizane ndi mankhwala ena.
Kumbukirani kuti zakudya zowonjezera zakudya ndi zitsamba sizinayesedwe mozama ndi kuyesa monga mankhwala ogulitsidwa ndi mankhwala, kutanthauza kuti kafukufuku wochirikiza mphamvu zawo ndi chitetezo chake ndi ochepa kapena osakwanira.
Zowonjezera ndi mankhwala achilengedwe amatha kukhala okongola, makamaka ngati alibe zotsatirapo. Ndipotu, mankhwala achilengedwe atsimikizira kuti ndi othandiza pa matenda ambiri. Pali umboni wosonyeza kuti ma magnesium owonjezera amatha kuchepetsa pafupipafupi komanso kuopsa kwa migraine. Komabe, sizikudziwika ngati 5-HTP ndi yopindulitsa kwa mutu waching'alang'ala.
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Teri Robert Teri Robert ndi mlembi, wophunzitsa odwala, komanso woleza mtima wodziwa za migraines ndi mutu.