Mankhwala ena otchedwa 5-hydroxytryptophan (5-HTP) kapena osetriptan amaonedwa kuti ndi amodzi mwa mankhwala ena ochizira mutu ndi mutu waching'alang'ala. Thupi limasintha mankhwalawa kukhala serotonin (5-HT), yomwe imadziwikanso kuti serotonin, neurotransmitter yomwe imayang'anira momwe munthu akumvera komanso ululu.
Kuchuluka kwa serotonin m'thupi nthawi zambiri kumawoneka mwa anthu omwe ali ndi vuto la kuvutika maganizo, koma anthu omwe ali ndi mutu waching'alang'ala komanso omwe ali ndi mutu wautali amathanso kukhala ndi serotonin yochepa panthawi ya kuukira komanso pakati pa kuukirako. Sizikudziwika chifukwa chake mutu waching'alang'ala ndi serotonin zimagwirizanitsidwa. Chiphunzitso chodziwika bwino ndi chakuti kusowa kwa serotonin kumapangitsa anthu kukhala ndi chidwi kwambiri ndi ululu.
Chifukwa cha kugwirizana kumeneku, njira zingapo zowonjezera ntchito ya serotonin muubongo zimagwiritsidwa ntchito kwambiri popewa mutu waching'alang'ala ndikuchiza matenda oopsa.
5-HTP ndi amino acid yomwe imapangidwa ndi thupi kuchokera ku amino acid yofunika kwambiri ya L-tryptophan ndipo iyenera kupezeka kuchokera ku chakudya. L-tryptophan imapezeka muzakudya monga mbewu, soya, Turkey ndi tchizi. Ma enzyme mwachibadwa amasintha L-tryptophan kukhala 5-HTP, kenako amasintha 5-HTP kukhala 5-HT.
Ma supplements a 5-HTP amapangidwa kuchokera ku chomera chamankhwala cha ku West Africa chotchedwa Griffonia simplicifolia. Supplement iyi yakhala ikugwiritsidwa ntchito pochiza kuvutika maganizo, fibromyalgia, chronic fatigue syndrome, komanso kuchepetsa thupi, koma palibe umboni wotsimikizika wa ubwino wake.
Mukamaganizira za 5-HTP kapena china chilichonse chowonjezera chachilengedwe, ndikofunikira kumvetsetsa kuti mankhwalawa ndi mankhwala. Ngati muwamwa chifukwa ali ndi mphamvu zokwanira zokhutiritsa thanzi lanu, kumbukirani kuti akhozanso kukhala ndi mphamvu zokwanira zokhutiritsa thanzi lanu.
Sizikudziwika ngati zowonjezera za 5-HTP zili zothandiza pa mutu waching'alang'ala kapena mitundu ina ya mutu. Ponseponse, kafukufuku ndi wochepa; maphunziro ena akuwonetsa kuti zimathandiza, pomwe ena sawonetsa zotsatira zake.
Kafukufuku wa mutu waching'alang'ala wagwiritsa ntchito mlingo wa 5-HTP kuyambira 25 mpaka 200 mg patsiku mwa akuluakulu. Pakadali pano palibe mlingo womveka bwino kapena wovomerezeka wa chowonjezera ichi, koma ndikofunikira kudziwa kuti mlingo wokwera umagwirizana ndi zotsatirapo zake komanso kuyanjana kwa mankhwala.
5-HTP ingagwirizane ndi mankhwala ena, kuphatikizapo carbidopa, yomwe imagwiritsidwa ntchito pochiza matenda a Parkinson. Ingagwirizanenso ndi ma triptan, ma SSRI, ndi ma monoamine oxidase inhibitors (MAOIs, gulu lina la mankhwala oletsa kuvutika maganizo).
Zakudya zowonjezera za Tryptophan ndi 5-HTP zitha kukhala ndi poizoni wachilengedwe wa 4,5-tryptophanione, womwe ndi poizoni wa neurotoxin womwe umadziwikanso kuti Peak X. Zotsatira za kutupa kwa Peak X zingayambitse kupweteka kwa minofu, kupweteka m'mimba, komanso malungo. Zotsatira za nthawi yayitali zitha kuphatikizapo kuwonongeka kwa minofu ndi mitsempha.
Popeza mankhwala amenewa ndi opangidwa ndi mankhwala osati odetsedwa kapena odetsa, amapezeka mu zowonjezera zakudya ngakhale zitakonzedwa bwino.
Ndikofunikira kukambirana ndi dokotala wanu kapena wamankhwala za kumwa mankhwala ena owonjezera kuti muwonetsetse kuti ndi otetezeka kwa inu ndipo sadzasokonezana ndi mankhwala ena omwe mumagwiritsa ntchito.
Kumbukirani kuti zakudya ndi zowonjezera zitsamba sizinachitike kafukufuku wozama komanso woyesedwa mofanana ndi mankhwala operekedwa ndi dokotala kapena omwe amaperekedwa ndi dokotala, zomwe zikutanthauza kuti kafukufuku wothandiza kuti agwire bwino ntchito komanso chitetezo chake ndi chochepa kapena chosakwanira.
Zakudya zowonjezera ndi mankhwala achilengedwe zimatha kukhala zokopa, makamaka ngati sizili ndi zotsatirapo zoyipa. Ndipotu, mankhwala achilengedwe atsimikizira kuti ndi othandiza pa matenda ambiri. Pali umboni wakuti zakudya zowonjezera za magnesium zimatha kuchepetsa kuchuluka ndi kuopsa kwa mutu waching'alang'ala. Komabe, sizikudziwika ngati 5-HTP ndi yothandiza pa mutu waching'alang'ala.
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Teri Robert Teri Robert ndi wolemba, mphunzitsi wodwala, komanso wolimbikitsa odwala omwe amadziwika bwino ndi mutu waching'alang'ala ndi mutu.