Thupi lanu limagwiritsa ntchito kupanga serotonin, messenger yamankhwala yomwe imatumiza chizindikiro pakati pa maselo amitsempha.
Kutsika kwa serotonin kumalumikizidwa ndi kupsinjika maganizo, nkhawa, kusokonezeka kwa kugona, kunenepa kwambiri, ndi mavuto ena azaumoyo (1, 2).
Kuonda kumawonjezera kupanga kwa mahomoni omwe amayambitsa njala. Kumva njala nthawi zonse kungapangitse kuchepa thupi kukhala kosakhazikika pakapita nthawi (3, 4, 5).
5-HTP imatha kuthana ndi mahomoni opangitsa njala awa omwe amalepheretsa kudya ndikukuthandizani kuti muchepetse thupi (6).
Mu kafukufuku wina, odwala 20 odwala matenda a shuga anapatsidwa mwachisawawa kuti alandire 5-HTP kapena placebo kwa milungu iwiri. Zotsatira zake zidawonetsa kuti omwe adalandira 5-HTP amadya pafupifupi 435 zopatsa mphamvu zochepa patsiku poyerekeza ndi gulu la placebo (7).
Kuphatikiza apo, 5-HTP makamaka imachepetsa kudya kwamafuta, komwe kumalumikizidwa ndi kuwongolera bwino kwa glycemic (7).
Kafukufuku wina wambiri wawonetsanso kuti 5-HTP imachulukitsa kukhuta ndikulimbikitsa kuchepa thupi kwa anthu onenepa kwambiri kapena onenepa kwambiri (8, 9, 10, 11).
Kuphatikiza apo, kafukufuku wa nyama awonetsa kuti 5-HTP imatha kuchepetsa kudya kwambiri chifukwa cha kupsinjika kapena kukhumudwa (12, 13).
5-HTP ikhoza kukhala yothandiza pakukulitsa kukhuta, zomwe zingakuthandizeni kudya pang'ono ndikuchepetsa thupi.
Ngakhale chomwe chimayambitsa kukhumudwa sichidziwika, ofufuza ena amakhulupirira kuti kusalinganika kwa serotonin kumatha kukhudza momwe mumamvera, zomwe zimayambitsa kukhumudwa (14, 15).
Ndipotu, maphunziro angapo ang'onoang'ono asonyeza kuti 5-HTP ikhoza kuchepetsa zizindikiro za kuvutika maganizo. Komabe, awiri a iwo sanagwiritse ntchito placebo poyerekezera, zomwe zimalepheretsa zotsatira zawo (16, 17, 18, 19).
Komabe, kafukufuku wambiri wasonyeza kuti 5-HTP ili ndi mphamvu yoletsa kukhumudwa ikagwiritsidwa ntchito limodzi ndi zinthu zina kapena antidepressants kuposa ikugwiritsidwa ntchito yokha (17, 21, 22, 23).
Kuphatikiza apo, ndemanga zambiri zatsimikizira kuti kafukufuku wapamwamba kwambiri amafunikira 5-HTP isanavomerezedwe pochiza kukhumudwa (24, 25).
Zowonjezera za 5-HTP zimawonjezera kuchuluka kwa serotonin m'thupi, zomwe zimatha kuthetsa zizindikiro za kuvutika maganizo, makamaka ngati ziphatikizidwa ndi mankhwala ena ovutika maganizo kapena mankhwala. Komabe, kufufuza kowonjezereka kumafunika.
5-HTP supplementation ikhoza kusintha zizindikiro za fibromyalgia, matenda omwe amadziwika ndi kupweteka kwa minofu ndi mafupa komanso kufooka kwakukulu.
Pakali pano palibe chifukwa chodziwika cha fibromyalgia, koma milingo yotsika ya serotonin idalumikizidwa ndi vutoli (26Trusted Source).
Izi zimapangitsa ochita kafukufuku kukhulupirira kuti kulimbikitsa milingo ya serotonin yokhala ndi zowonjezera za 5-HTP zitha kupindulitsa anthu omwe ali ndi fibromyalgia (27).
Ndipotu, umboni woyambirira umasonyeza kuti 5-HTP ikhoza kusintha zizindikiro za fibromyalgia, kuphatikizapo kupweteka kwa minofu, vuto la kugona, nkhawa, ndi kutopa (28, 29, 30).
Komabe, palibe kafukufuku wokwanira yemwe wapangidwa kuti atsimikize zowona za mphamvu ya 5-HTP pakuwongolera zizindikiro za fibromyalgia.
5-HTP imachulukitsa kuchuluka kwa serotonin m'thupi, zomwe zimatha kuthetsa zina mwa zizindikiro za fibromyalgia. Komabe, kufufuza kowonjezereka kumafunika.
5-HTP imanenedwa kuti imathandiza kuchiza mutu waching'alang'ala, mtundu wa mutu womwe nthawi zambiri umatsagana ndi nseru kapena kusokonezeka kwa maso.
Ngakhale chifukwa chake chenicheni chimatsutsana, ofufuza ena amakhulupirira kuti amayamba chifukwa cha kuchepa kwa serotonin (31, 32).
Kafukufuku wa anthu 124 adayerekeza kuthekera kwa 5-HTP ndi methylergometrine, mankhwala omwe amagwiritsidwa ntchito pochiza mutu waching'alang'ala (33).
Kafukufuku adapeza kuti kutenga 5-HTP tsiku lililonse kwa miyezi isanu ndi umodzi kumalepheretsa kapena kuchepetsa kwambiri kuchuluka kwa migraine mu 71% ya omwe adatenga nawo gawo (33).
Mu kafukufuku wina wa ophunzira a 48, 5-HTP inachepetsa kupweteka kwa mutu ndi 70% poyerekeza ndi 11% mu gulu la placebo (34).
Momwemonso, maphunziro ena ambiri awonetsa kuti 5-HTP ikhoza kukhala chithandizo chothandizira migraines (30, 35, 36).
Melatonin imagwira ntchito yofunika kwambiri pakuwongolera kugona. Miyezo yake imayamba kukwera usiku kuti ilimbikitse kugona ndikugwa m'mawa kuti ikuthandizeni kudzuka.
Choncho, 5-HTP supplementation ingalimbikitse kugona mwa kuonjezera kupanga melatonin m'thupi.
Kafukufuku wa anthu adapeza kuti kuphatikiza kwa 5-HTP ndi gamma-aminobutyric acid (GABA) kumachepetsa kwambiri nthawi yomwe imafunika kuti munthu agone, kuchuluka kwa nthawi yogona, komanso kugona bwino (37).
GABA ndi messenger wamankhwala omwe amalimbikitsa kupumula. Kuphatikiza ndi 5-HTP kumatha kukhala ndi synergistic effect (37).
M'malo mwake, maphunziro angapo a nyama ndi tizilombo awonetsa kuti 5-HTP imathandizira kugona bwino ndipo imakhala yabwinoko ikaphatikizidwa ndi GABA (38, 39).
Ngakhale kuti zotsatirazi zikulonjeza, kusowa kwa maphunziro a anthu kumapangitsa kuti zikhale zovuta kulangiza 5-HTP kuti ikhale yabwino, makamaka ikagwiritsidwa ntchito yokha.
Anthu ena amatha kumva nseru, kutsekula m'mimba, kusanza, ndi kupweteka m'mimba akamamwa zowonjezera 5-HTP. Zotsatira zoyipazi zimatengera mlingo, kutanthauza kuti zimakulirakulira pamene mlingo ukuwonjezeka (33).
Kuti muchepetse zotsatirazi, yambani ndi mlingo wa 50-100 mg kawiri tsiku lililonse ndikuwonjezera mlingo woyenera pakadutsa milungu iwiri (40).
Mankhwala ena amawonjezera kupanga serotonin. Kuphatikiza mankhwalawa ndi 5-HTP kungayambitse milingo yowopsa ya serotonin m'thupi. Izi zimatchedwa serotonin syndrome, vuto lomwe lingakhale pachiwopsezo cha moyo (41).
Mankhwala omwe angapangitse kuchuluka kwa serotonin m'thupi kumaphatikizapo mankhwala ochepetsa kupsinjika maganizo, mankhwala a chifuwa, kapena mankhwala ochepetsa ululu.
Chifukwa 5-HTP ikhoza kulimbikitsanso kugona, kuitenga ndi mankhwala osokoneza bongo monga Klonopin, Ativan, kapena Ambien kungayambitse kugona kwambiri.
Chifukwa cha kusagwirizana komwe kungachitike ndi mankhwala ena, funsani dokotala kapena wazamankhwala musanatenge zowonjezera za 5-HTP.
Mukamagula zowonjezera, yang'anani zisindikizo za NSF kapena USP zomwe zimasonyeza khalidwe lapamwamba. Awa ndi makampani a chipani chachitatu omwe amatsimikizira kuti zowonjezerazo zili ndi zomwe zanenedwa palembapo ndipo zilibe zonyansa.
Anthu ena amatha kukhala ndi zotsatira zoyipa akamamwa zowonjezera 5-HTP. Yang'anani ndi dokotala musanatenge 5-HTP kuti muwonetsetse kuti ndi yabwino kwa inu.
Zowonjezera izi ndizosiyana ndi zowonjezera za L-tryptophan, zomwe zimatha kuonjezera milingo ya serotonin (42).
L-tryptophan ndi amino acid ofunikira omwe amapezeka muzakudya zokhala ndi mapuloteni ambiri monga mkaka, nkhuku, nyama, nandolo, ndi soya.
Kumbali ina, 5-HTP sichipezeka muzakudya ndipo imatha kuwonjezeredwa kuzakudya zanu kudzera muzakudya zowonjezera (43).
Thupi lanu limasintha 5-HTP kukhala serotonin, chinthu chomwe chimayang'anira chilakolako cha kudya, kumva ululu, ndi kugona.
Miyezo yapamwamba ya serotonin ikhoza kukhala ndi ubwino wambiri, monga kuchepa thupi, mpumulo ku zizindikiro za kuvutika maganizo ndi fibromyalgia, kuchepetsa maulendo a migraine, komanso kugona bwino.
Zotsatira zing'onozing'ono zakhala zikugwirizana ndi 5-HTP, koma izi zikhoza kuchepetsedwa poyambira ndi mankhwala ang'onoang'ono ndikuwonjezera pang'onopang'ono mlingo.
Popeza kuti 5-HTP ingagwirizane molakwika ndi mankhwala ena, funsani dokotala kuti muwonetsetse kuti ndi otetezeka kwa inu.
Akatswiri athu nthawi zonse amayang'anitsitsa malo athanzi ndi thanzi ndikusintha zolemba zathu pomwe zatsopano zikupezeka.
5-HTP imagwiritsidwa ntchito ngati chowonjezera kuti muwonjezere kuchuluka kwa serotonin. Ubongo umagwiritsa ntchito serotonin kuwongolera maganizo, chilakolako, ndi ntchito zina zofunika. koma…
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