Thupi lanu limagwiritsa ntchito serotonin, yomwe ndi mankhwala omwe amatumiza mauthenga pakati pa maselo a mitsempha.
Kuchepa kwa serotonin kwagwirizanitsidwa ndi kuvutika maganizo, nkhawa, kusokonezeka kwa tulo, kunenepa, ndi mavuto ena azaumoyo (1, 2).
Kuchepetsa thupi kumawonjezera kupanga mahomoni omwe amayambitsa njala. Kumva njala kosalekeza kumeneku kungapangitse kuti kuchepetsa thupi kusapitirire kwa nthawi yayitali (3, 4, 5).
5-HTP ingagonjetse mahomoni oyambitsa njala omwe amaletsa chilakolako cha chakudya ndikukuthandizani kuchepetsa thupi (6).
Mu kafukufuku wina, odwala 20 odwala matenda a shuga anapatsidwa mwachisawawa kuti alandire 5-HTP kapena placebo kwa milungu iwiri. Zotsatira zake zinasonyeza kuti omwe adalandira 5-HTP ankadya pafupifupi ma calories 435 ochepa patsiku poyerekeza ndi gulu la placebo (7).
Komanso, 5-HTP imaletsa kudya chakudya cham'thupi, chomwe chimagwirizana ndi kuwongolera bwino shuga m'magazi (7).
Kafukufuku wina wambiri wasonyezanso kuti 5-HTP imawonjezera kukhuta ndipo imalimbikitsa kuchepetsa thupi mwa anthu onenepa kwambiri kapena onenepa kwambiri (8, 9, 10, 11).
Kuphatikiza apo, kafukufuku wa nyama wasonyeza kuti 5-HTP ingachepetse kudya kwambiri chifukwa cha kupsinjika maganizo kapena kuvutika maganizo (12, 13).
5-HTP ingathandize kwambiri pakukhuta, zomwe zingakuthandizeni kudya pang'ono komanso kuchepetsa thupi.
Ngakhale kuti chifukwa chenicheni cha kuvutika maganizo sichikudziwika kwenikweni, ofufuza ena amakhulupirira kuti kusalinganika kwa serotonin kungakhudze momwe mumamvera, zomwe zimapangitsa kuti mukhale ndi kuvutika maganizo (14, 15).
Ndipotu, kafukufuku wochepa wasonyeza kuti 5-HTP imatha kuchepetsa zizindikiro za kuvutika maganizo. Komabe, awiri mwa iwo sanagwiritse ntchito placebo poyerekeza, zomwe zinachepetsa kutsimikizika kwa zotsatira zawo (16, 17, 18, 19).
Komabe, kafukufuku wambiri wasonyeza kuti 5-HTP imakhala ndi mphamvu yowonjezereka yochepetsera nkhawa ikagwiritsidwa ntchito limodzi ndi zinthu zina kapena mankhwala ochepetsera nkhawa kuposa ikagwiritsidwa ntchito yokha (17, 21, 22, 23).
Kuphatikiza apo, ndemanga zambiri zatsimikiza kuti kafukufuku wapamwamba kwambiri akufunika musanaperekedwe 5-HTP pochiza kuvutika maganizo (24, 25).
Zakudya zowonjezera 5-HTP zimawonjezera kuchuluka kwa serotonin m'thupi, zomwe zimatha kuchepetsa zizindikiro za kuvutika maganizo, makamaka zikaphatikizidwa ndi mankhwala ena ochepetsa nkhawa kapena mankhwala. Komabe, kafukufuku wowonjezereka akufunika.
Kuonjezera 5-HTP kungathandize kuchepetsa zizindikiro za fibromyalgia, matenda omwe amadziwika ndi kupweteka kwa minofu ndi mafupa komanso kufooka kwa thupi lonse.
Pakadali pano palibe chifukwa chodziwika bwino cha fibromyalgia, koma kuchuluka kwa serotonin komwe kumalumikizidwa ndi vutoli (26Trusted Source).
Izi zimapangitsa ofufuza kukhulupirira kuti kuwonjezera kuchuluka kwa serotonin ndi zowonjezera 5-HTP kungathandize anthu omwe ali ndi fibromyalgia (27).
Ndipotu, umboni woyambirira umasonyeza kuti 5-HTP ingachepetse zizindikiro za fibromyalgia, kuphatikizapo kupweteka kwa minofu, mavuto ogona, nkhawa, ndi kutopa (28, 29, 30).
Komabe, kafukufuku wokwanira sanachitike kuti apeze mfundo zomveka bwino zokhudza momwe 5-HTP imagwirira ntchito pochepetsa zizindikiro za fibromyalgia.
5-HTP imawonjezera kuchuluka kwa serotonin m'thupi, zomwe zimatha kuchepetsa zizindikiro zina za fibromyalgia. Komabe, kafukufuku wowonjezereka akufunika.
Akuti 5-HTP imathandiza kuchiza mutu waching'alang'ala, mtundu wa mutu womwe nthawi zambiri umatsagana ndi nseru kapena kusokonezeka kwa maso.
Ngakhale kuti chifukwa chenicheni cha matendawa chikukambidwa, ofufuza ena amakhulupirira kuti amayamba chifukwa cha kuchepa kwa serotonin (31, 32).
Kafukufuku wa anthu 124 anayerekeza mphamvu ya 5-HTP ndi methylergometrine, mankhwala odziwika bwino a mutu waching'alang'ala, popewa mutu waching'alang'ala (33).
Kafukufuku wina adapeza kuti kumwa 5-HTP tsiku lililonse kwa miyezi isanu ndi umodzi kunaletsa kapena kuchepetsa kwambiri kuchuluka kwa migraine mwa 71% ya omwe adatenga nawo gawo (33).
Mu kafukufuku wina wa ophunzira 48, 5-HTP inachepetsa kupweteka mutu ndi 70% poyerekeza ndi 11% m'gulu la placebo (34).
Mofananamo, maphunziro ena ambiri asonyeza kuti 5-HTP ikhoza kukhala mankhwala othandiza a mutu waching'alang'ala (30, 35, 36).
Melatonin imagwira ntchito yofunika kwambiri pakulamulira tulo. Mlingo wake umayamba kukwera usiku kuti uthandize tulo ndipo umatsika m'mawa kuti uthandize kudzuka.
Chifukwa chake, kuwonjezera 5-HTP kungathandize tulo powonjezera kupanga melatonin m'thupi.
Kafukufuku wa anthu adapeza kuti kuphatikiza kwa 5-HTP ndi gamma-aminobutyric acid (GABA) kumachepetsa kwambiri nthawi yomwe imatenga kuti munthu agone, kumawonjezera nthawi yogona, komanso kumawonjezera ubwino wa kugona (37).
GABA ndi mankhwala omwe amalimbikitsa kupumula. Kuphatikiza ndi 5-HTP kungakhale ndi mphamvu yogwirizana (37).
Ndipotu, kafukufuku wochuluka wa zinyama ndi tizilombo wasonyeza kuti 5-HTP imapangitsa kuti munthu azigona bwino ndipo imakhala yabwino kwambiri ikaphatikizidwa ndi GABA (38, 39).
Ngakhale kuti zotsatirazi zili ndi chiyembekezo, kusowa kwa maphunziro a anthu kumapangitsa kuti zikhale zovuta kupereka 5-HTP kuti munthu agone bwino, makamaka akagwiritsidwa ntchito payekha.
Anthu ena amatha kumva nseru, kutsegula m'mimba, kusanza, ndi kupweteka m'mimba akamamwa ma supplements a 5-HTP. Zotsatirapozi zimadalira mlingo, zomwe zikutanthauza kuti zimakula kwambiri pamene mlingo ukuwonjezeka (33).
Kuti muchepetse zotsatirapo zoyipazi, yambani ndi mlingo wa 50–100 mg kawiri patsiku ndikuwonjezera mlingo woyenera kwa milungu iwiri (40).
Mankhwala ena amawonjezera kupanga serotonin. Kuphatikiza mankhwalawa ndi 5-HTP kungayambitse kuchuluka kwa serotonin m'thupi. Izi zimatchedwa serotonin syndrome, vuto lomwe lingathe kupha munthu (41).
Mankhwala omwe angawonjezere kuchuluka kwa serotonin m'thupi ndi monga mankhwala ena oletsa kuvutika maganizo, mankhwala a chifuwa, kapena mankhwala ochepetsa ululu omwe amaperekedwa ndi dokotala.
Popeza 5-HTP ingathandizenso kugona, kumwa pamodzi ndi mankhwala oletsa kugona monga Klonopin, Ativan, kapena Ambien kungayambitse kugona kwambiri.
Chifukwa cha kusagwirizana ndi mankhwala ena, funsani dokotala wanu kapena wamankhwala musanamwe zowonjezera za 5-HTP.
Mukagula zowonjezera, yang'anani zizindikiro za NSF kapena USP zomwe zimasonyeza kuti ndi zapamwamba. Izi ndi makampani ena omwe amatsimikiza kuti zowonjezerazo zili ndi zomwe zalembedwa pa chizindikirocho ndipo zilibe zodetsa.
Anthu ena angakumane ndi zotsatirapo zoyipa akamamwa mankhwala owonjezera a 5-HTP. Funsani dokotala musanamwe 5-HTP kuti muwonetsetse kuti ndi yotetezeka kwa inu.
Zakudya zowonjezera izi ndizosiyana ndi zakudya zowonjezera za L-tryptophan, zomwe zimathanso kuwonjezera kuchuluka kwa serotonin (42).
L-tryptophan ndi amino acid yofunika kwambiri yomwe imapezeka muzakudya zokhala ndi mapuloteni ambiri monga mkaka, nkhuku, nyama, nandolo, ndi soya.
Kumbali inayi, 5-HTP siipezeka mu chakudya ndipo ingangowonjezedwa muzakudya zanu kudzera mu zakudya zowonjezera (43).
Thupi lanu limasintha 5-HTP kukhala serotonin, chinthu chomwe chimayang'anira chilakolako cha chakudya, kumva ululu, komanso kugona.
Kuchuluka kwa serotonin m'thupi kungathandize kwambiri, monga kuchepetsa thupi, kuchepetsa zizindikiro za kuvutika maganizo ndi fibromyalgia, kuchepetsa kupweteka kwa mutu pafupipafupi, komanso kugona bwino.
Zotsatirapo zazing'ono zakhala zikugwirizana ndi 5-HTP, koma izi zitha kuchepetsedwa poyambira ndi mlingo wochepa ndikuwonjezera pang'onopang'ono mlingo.
Popeza 5-HTP ingakhudze mankhwala ena, funsani dokotala wanu kuti muwonetsetse kuti ndi yotetezeka kwa inu.
Akatswiri athu nthawi zonse amayang'anira thanzi ndi thanzi labwino ndikusintha nkhani zathu pamene chidziwitso chatsopano chikupezeka.
5-HTP imagwiritsidwa ntchito kwambiri ngati chowonjezera kuti iwonjezere kuchuluka kwa serotonin. Ubongo umagwiritsa ntchito serotonin kuti ulamulire momwe munthu akumvera, chilakolako chofuna kudya, ndi ntchito zina zofunika. koma…
Kodi Xanax imagwira ntchito bwanji pochiza kuvutika maganizo? Xanax imagwiritsidwa ntchito kwambiri pochiza nkhawa ndi mantha.