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Pakafukufuku waposachedwa wofalitsidwa mu nyuzipepala ya Pharmaceutics, ofufuza adatsimikiza za mphamvu ya antimicrobial ya mankhwala azitsamba otchedwa FRO motsutsana ndi acne pathogenesis.
Kuwunika kwa antimicrobial komanso kuwunika kwa in vitro kunawonetsa kuti FRO ili ndi antibacterial ndi anti-inflammatory effect motsutsana ndi Dermatobacillus Acnes (CA), bakiteriya yemwe amayambitsa ziphuphu. Zotsatirazi zikuwonetsa kugwiritsa ntchito kwake kotetezeka komanso kwachilengedwe pakuchiritsa zodzikongoletsera za ziphuphu zakumaso, kuthandizira kugwiritsa ntchito njira zopanda poizoni komanso zotsika mtengo m'malo mwamankhwala amakono a ziphuphu zakumaso.
Phunziro: Kuchita bwino kwa FRO mu pathogenesis ya acne vulgaris. Chithunzi chojambula: Steve Jungs/Shutterstock.com
Acne vulgaris, omwe amadziwika kuti pimples, ndi vuto la khungu lomwe limayamba chifukwa cha zipolopolo za tsitsi zomwe zimakhala ndi sebum ndi maselo akufa. Ziphuphu zimakhudza achinyamata oposa 80 pa 100 aliwonse ndipo, ngakhale kuti sizipha, zingayambitse kuvutika maganizo, ndipo zikavuta kwambiri, khungu limakhala ndi mtundu wa pigment ndi mabala.
Ziphuphu zimachitika chifukwa cha kuyanjana kwa majini ndi chilengedwe, zomwe nthawi zambiri zimayamba chifukwa cha kusintha kwa mahomoni komwe kumatsagana ndi kutha msinkhu. Kusagwirizana kwa mahomoniwa kumawonjezera kupanga sebum ndikuwonjezera insulin kukula factor 1 (IGF-1) ndi dihydrotestosterone (DHT) ntchito.
Kuchulukitsa katulutsidwe ka sebum kumawonedwa ngati gawo loyamba pakukula kwa ziphuphu zakumaso, popeza tsitsi lodzaza ndi sebum lili ndi tizilombo tambiri monga SA. SA ndi chilengedwe commensal mankhwala a khungu; komabe, kuchulukirachulukira kwa phylotype IA1 yake kumayambitsa kutupa ndi mtundu wa ma follicle atsitsi okhala ndi ma papules owonekera kunja.
Pali zodzoladzola zosiyanasiyana zochizira ziphuphu zakumaso, monga ma retinoids ndi ma topical microbial agents, omwe amagwiritsidwa ntchito limodzi ndi ma peels amankhwala, laser/light therapy, ndi mahomoni. Komabe, mankhwalawa ndi okwera mtengo ndipo amakhudzana ndi zotsatira zoyipa.
Kafukufuku wam'mbuyomu adafufuza zopangira zitsamba ngati njira yotsika mtengo yachilengedwe kumankhwala awa. M'malo mwake, zotulutsa za Rhus vulgaris (RV) zaphunziridwa. Komabe, kugwiritsidwa ntchito kwake kumachepetsedwa ndi urushiol, chigawo chachikulu cha allergenic cha mtengo uwu.
FRO ndi mankhwala azitsamba omwe ali ndi zotulutsa zofufumitsa za RV (FRV) ndi Japanese mangosteen (OJ) mu chiŵerengero cha 1:1. Kugwira ntchito kwa fomuyi kwayesedwa pogwiritsa ntchito ma in vitro assays ndi antimicrobial properties.
Kusakaniza kwa FRO kudadziwika koyamba pogwiritsa ntchito high performance liquid chromatography (HPLC) kudzipatula, kuzindikira ndi kuwerengera zigawo zake. Chosakanizacho chinawunikidwanso kuti chikhale ndi phenolic content (TPC) kuti azindikire mankhwala omwe angakhale ndi antimicrobial properties.
Preliminary in vitro antimicrobial assay powunika kukhudzidwa kwa disc diffusion. Choyamba, CA (phylotype IA1) inakonzedwa mofanana pa mbale ya agar yomwe 10 mm diameter FRO-impregnated froter paper disk disk inayikidwa. Ntchito ya antimicrobial inayesedwa poyesa kukula kwa dera loletsa.
Kuchita bwino kwa FRO pakupanga sebum yopangidwa ndi CA ndi ma androgen okhudzana ndi DHT adawunikidwa pogwiritsa ntchito utoto wa Mafuta Ofiira ndi kusanthula kwa blot waku Western, motsatana. Pambuyo pake, FRO inayesedwa kuti ingathe kuthetsa zotsatira za mitundu yogwira ntchito ya okosijeni (ROS), yomwe imayambitsa ziphuphu za hyperpigmentation ndi zipsera za pambuyo pa opaleshoni, pogwiritsa ntchito kafukufuku wa 2',7'-dichlorofluorescein diacetate (DCF-DA). chifukwa.
Zotsatira za kuyesa kwa disk diffusion zinasonyeza kuti 20 μL ya FRO inalepheretsa kukula kwa CA ndipo inapanga malo owonetsetsa a 13 mm pamagulu a 100 mg / mL. FRO imachepetsa kwambiri kuchuluka kwa katulutsidwe ka sebum komwe kumayambitsidwa ndi SA, potero kumachepetsa kapena kubweza kuyambika kwa ziphuphu zakumaso.
FRO yapezeka kuti ili ndi zinthu zambiri za phenolic kuphatikiza gallic acid, kaempferol, quercetin ndi fisetin. Chiwerengero chonse cha phenolic compound (TPC) chinali 118.2 mg gallic acid ofanana (GAE) pa gram FRO.
FRO yachepetsa kwambiri kutupa kwa ma cell komwe kumayambitsidwa ndi SA-induced ROS ndi kutulutsidwa kwa cytokine. Kuchepetsa kwa nthawi yayitali kupanga ROS kungachepetse hyperpigmentation ndi zipsera.
Ngakhale mankhwala a dermatological a acne alipo, nthawi zambiri amakhala okwera mtengo ndipo amatha kukhala ndi zotsatira zosafunika.
Zotsatira zikuwonetsa kuti FRO ili ndi antibacterial properties motsutsana ndi CA (mabakiteriya oyambitsa ziphuphu), motero akuwonetsa kuti FRO ndi njira yachilengedwe, yopanda poizoni komanso yotsika mtengo kusiyana ndi mankhwala a acne. FRO imachepetsanso kupanga sebum ndi kutulutsa kwa mahomoni mu vitro, kuwonetsa mphamvu yake pochiza ndi kupewa ziphuphu zakumaso.
Mayesero am'mbuyomu a FRO adawonetsa kuti anthu omwe amagwiritsa ntchito toner ndi mafuta odzola apamwamba a FRO adawona kusintha kwakukulu pakhungu komanso kuchuluka kwa chinyezi poyerekeza ndi gulu lowongolera patangotha ​​milungu isanu ndi umodzi yokha. Ngakhale kuti phunziroli silinayang'ane ziphuphu zomwe zimayendetsedwa mu vitro, zotsatira zaposachedwa zimathandizira zomwe apeza.
Kuphatikizidwa pamodzi, zotsatirazi zimathandizira kugwiritsidwa ntchito kwamtsogolo kwa FRO mu zodzikongoletsera, kuphatikiza chithandizo cha ziphuphu zakumaso komanso kukonza thanzi lakhungu.
Nkhaniyi idasinthidwa pa June 9, 2023 kuti m'malo mwa chithunzi chachikulu ndi choyenera.
Yolembedwa mu: Medical Science News | Nkhani Zofufuza Zamankhwala | Nkhani Za Matenda | Nkhani zamankhwala
Tags: ziphuphu zakumaso, achinyamata, androgens, odana ndi yotupa, maselo, chromatography, cytokines, dihydrotestosterone, mphamvu, nayonso mphamvu, majini, kukula zinthu, tsitsi, mahomoni, hyperpigmentation, mu m'galasi, kutupa, insulini, phototherapy, madzi chromatography, mpweya, kuchuluka , quercetin , retinoids, khungu, maselo a khungu, pigmentation ya khungu, Western blot
Hugo Francisco de Souza ndi wolemba sayansi yemwe amakhala ku Bangalore, Karnataka, India. Zokonda zake zamaphunziro ndi za biogeography, evolutionary biology ndi herpetology. Panopa akugwira ntchito yolemba udokotala. kuchokera ku Center for Environmental Sciences ku Indian Institute of Science, komwe amaphunzira za chiyambi, kagawidwe ndi kafotokozedwe ka njoka za m'dambo. Hugo analandira DST-INSPIRE Fellowship chifukwa cha kafukufuku wake wa udokotala komanso Mendulo ya Golide yochokera ku yunivesite ya Pondicherry chifukwa cha kupambana kwake pa maphunziro pa maphunziro ake a Master. Kafukufuku wake wasindikizidwa m'magazini omwe amawunikiridwa ndi anzawo kuphatikizapo PLOS Neglected Tropical Diseases and Systems Biology. Akapanda kugwira ntchito ndikulemba, Hugo amangokhalira kuseketsa matani anime ndi nthabwala, amalemba ndikulemba nyimbo pagitala la bass, amadula nyimbo pa MTB, amasewera masewera apakanema (amakonda mawu oti "masewera"), kapena kungoyimba ndi chilichonse. . matekinoloje.
Francisco de Souza, Hugo. (Julayi 9, 2023). Kuphatikizika kwapadera kwa zitsamba zamitengo kumapereka mapindu amphamvu odana ndi ziphuphu. Nkhani - Zachipatala. Inabwezedwa pa Seputembara 11, 2023, kuchokera ku https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. "Kuphatikiza kwapadera kwa zitsamba zokhala ndi zotsutsana ndi ziphuphu zamphamvu." Nkhani - Zachipatala. Seputembara 11, 2023.
Francisco de Souza, Hugo. "Kuphatikiza kwapadera kwa zitsamba zokhala ndi zotsutsana ndi ziphuphu zamphamvu." Nkhani - Zachipatala. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Yafikira Seputembara 11, 2023).
Francisco de Souza, Hugo. 2023. Kuphatikizika kwapadera kwa zitsamba zokhala ndi zotsutsana ndi ziphuphu zamphamvu. News Medical, yofikira pa Seputembara 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
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