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Mu kafukufuku waposachedwa wofalitsidwa mu magazini ya Pharmaceutics, ofufuza adapeza kuti mankhwala azitsamba otchedwa FRO ndi othandiza polimbana ndi ziphuphu.
Kuwunika kwa maantibayotiki ndi kusanthula kwa m'thupi kunawonetsa kuti FRO ili ndi mphamvu yolimbana ndi mabakiteriya komanso kutupa motsutsana ndi Dermatobacillus Acnes (CA), bakiteriya yomwe imayambitsa ziphuphu. Zotsatirazi zikuwonetsa kuti imagwiritsidwa ntchito bwino komanso mwachilengedwe pochiza ziphuphu, zomwe zimathandiza kugwiritsa ntchito njira zina zopanda poizoni komanso zotsika mtengo m'malo mwa mankhwala a ziphuphu omwe alipo.
Kafukufuku: Kugwira ntchito kwa FRO pa matenda a ziphuphu. Chithunzi chojambulidwa ndi: Steve Jungs/Shutterstock.com
Matenda a ziphuphu, omwe amadziwikanso kuti ziphuphu, ndi vuto lofala pakhungu lomwe limayamba chifukwa cha kutsekeka kwa tsitsi ndi maselo a khungu akufa. Matenda a ziphuphu amakhudza achinyamata opitilira 80 peresenti ndipo, ngakhale kuti si oopsa, angayambitse kuvutika maganizo komanso, nthawi zina, kupangika kwa utoto ndi zipsera pakhungu kosatha.
Ziphuphu zimachitika chifukwa cha kuyanjana kwa majini ndi zinthu zachilengedwe, zomwe nthawi zambiri zimachitika chifukwa cha kusintha kwa mahomoni komwe kumachitika chifukwa cha kutha msinkhu. Kusalingana kwa mahomoni kumeneku kumawonjezera kupanga kwa sebum ndikuwonjezera ntchito ya insulin growth factor 1 (IGF-1) ndi dihydrotestosterone (DHT).
Kuchuluka kwa sebum secretion kumaonedwa ngati gawo loyamba pakukula kwa ziphuphu, popeza ma follicles a tsitsi odzaza ndi sebum ali ndi tizilombo tambiri monga SA. SA ndi chinthu chachilengedwe cha khungu; komabe, kuchuluka kwa phylotype IA1 yake kumayambitsa kutupa ndi utoto wa ma follicles a tsitsi ndi ma papules owoneka kunja.
Pali njira zosiyanasiyana zochiritsira ziphuphu, monga ma retinoids ndi mankhwala ophera tizilombo toyambitsa matenda, omwe amagwiritsidwa ntchito limodzi ndi ma peel a mankhwala, laser/light therapy, ndi mankhwala ophera mahomoni. Komabe, njira zimenezi ndi zodula kwambiri ndipo zimakhala ndi zotsatirapo zoyipa.
Kafukufuku wakale adafufuza zotsukira zitsamba ngati njira ina yachilengedwe yotsika mtengo m'malo mwa mankhwala awa. Monga njira ina, zotsukira za Rhus vulgaris (RV) zaphunziridwa. Komabe, kugwiritsidwa ntchito kwake kumachepetsedwa ndi urushiol, gawo lofunika kwambiri la ziwengo la mtengo uwu.
FRO ndi mankhwala azitsamba okhala ndi zotumphukira za RV (FRV) ndi mangosteen waku Japan (OJ) mu chiŵerengero cha 1:1. Kugwira ntchito kwa mankhwalawa kwayesedwa pogwiritsa ntchito mayeso a in vitro ndi mphamvu zophera tizilombo toyambitsa matenda.
Choyamba, kusakaniza kwa FRO kunadziwika pogwiritsa ntchito high performance liquid chromatography (HPLC) kuti apeze, adziwe ndikuwerengera zigawo zake. Kusakanizaku kunafufuzidwanso kuti adziwe kuchuluka kwa phenolic (TPC) kuti adziwe mankhwala omwe ali ndi mphamvu zotsutsana ndi mabakiteriya.
Kuyesa koyamba kwa maantibayotiki mu vitro poyesa kukhudzidwa kwa kufalikira kwa ma disc. Choyamba, CA (phylotype IA1) idakulitsidwa mofanana pa mbale ya agar pomwe diski ya pepala losefera ya mainchesi 10 mm idayikidwapo FRO-impregnated. Mphamvu ya maantibayotiki idayesedwa poyesa kukula kwa dera loletsa.
Kugwira ntchito kwa FRO pakupanga kwa sebum komwe kumayambitsa CA komanso kuchuluka kwa androgen komwe kumalumikizidwa ndi DHT kunayesedwa pogwiritsa ntchito utoto wa Oil Red ndi Western blot analysis, motsatana. Pambuyo pake FRO idayesedwa kuti ione ngati ingathe kuthetsa zotsatira za reactive oxygen species (ROS), zomwe zimayambitsa hyperpigmentation yokhudzana ndi ziphuphu ndi zipsera pambuyo pa opaleshoni, pogwiritsa ntchito probe ya 2′,7′-dichlorofluorescein diacetate (DCF-DA).
Zotsatira za kuyesa kwa kufalikira kwa ma disk zinasonyeza kuti 20 μL ya FRO inaletsa bwino kukula kwa CA ndipo inapanga malo owoneka ngati oletsa a 13 mm pamlingo wa 100 mg/mL. FRO imaletsa kwambiri kuwonjezeka kwa kutulutsa kwa sebum komwe kumachitika chifukwa cha SA, motero kumachepetsa kapena kubweza ziphuphu.
FRO yapezeka kuti ili ndi mankhwala ambiri a phenolic kuphatikizapo gallic acid, kaempferol, quercetin ndi fisetin. Kuchuluka kwa phenolic compound (TPC) kunali pafupifupi 118.2 mg gallic acid equivalents (GAE) pa gramu iliyonse ya FRO.
FRO inachepetsa kwambiri kutupa kwa maselo komwe kumachitika chifukwa cha SA-induced ROS ndi cytokine release. Kuchepetsa kwa nthawi yayitali kupanga ROS kungachepetse hyperpigmentation ndi zipsera.
Ngakhale kuti pali mankhwala a khungu a ziphuphu, nthawi zambiri amakhala okwera mtengo ndipo amatha kukhala ndi zotsatirapo zoyipa zambiri zosafunikira.
Zotsatira zake zikusonyeza kuti FRO ili ndi mphamvu zotsutsana ndi CA (mabakiteriya oyambitsa ziphuphu), motero zikusonyeza kuti FRO ndi njira yachilengedwe, yopanda poizoni komanso yotsika mtengo m'malo mwa mankhwala achikhalidwe a ziphuphu. FRO imachepetsanso kupanga sebum ndi kutulutsa mahomoni mkati mwa thupi, kusonyeza kuti imagwira ntchito bwino pochiza ndikuletsa kuphulika kwa ziphuphu.
Mayeso am'mbuyomu a zachipatala a FRO adawonetsa kuti anthu omwe amagwiritsa ntchito toner ndi lotion yapamwamba ya FRO adawona kusintha kwakukulu pakulimba kwa khungu ndi kuchuluka kwa chinyezi poyerekeza ndi gulu lowongolera patatha milungu isanu ndi umodzi yokha. Ngakhale kuti kafukufukuyu sanawunike ziphuphu pansi pa zochitika zolamulidwa mu vitro, zotsatira zaposachedwa zikugwirizana ndi zomwe adapeza.
Zotsatirazi zikuthandizira kugwiritsa ntchito FRO mtsogolo pochiza zodzoladzola, kuphatikizapo kuchiza ziphuphu ndi kukonza thanzi la khungu lonse.
Nkhaniyi idasinthidwa pa June 9, 2023 kuti chithunzi chachikulu chilowe m'malo mwake ndi choyenera kwambiri.
Yatumizidwa mu: Nkhani za Sayansi ya Zamankhwala | Nkhani Zofufuza Zachipatala | Nkhani Za Matenda | Nkhani Zamankhwala
Ma tag: ziphuphu, achinyamata, androgens, anti-inflammatory, maselo, chromatography, cytokines, dihydrotestosterone, effectiveness, fermentation, genetics, growth factors, hair, hormones, hyperpigmentation, in vitro, inflammation, insulin, phototherapy, liquid chromatography, oxygen, proliferation, quercetin, retinoids, skin, skin cells, skin pigmentation, Western blot
Hugo Francisco de Souza ndi wolemba sayansi wokhala ku Bangalore, Karnataka, India. Zokonda zake pamaphunziro zili m'magawo a biogeography, biology ya chisinthiko ndi herpetology. Pakadali pano akugwira ntchito pa dissertation yake ya udokotala, kuchokera ku Center for Environmental Sciences ku Indian Institute of Science, komwe amaphunzira za chiyambi, kufalikira, ndi kudziwika kwa njoka za m'madzi. Hugo adapatsidwa DST-INSPIRE Fellowship chifukwa cha kafukufuku wake wa udokotala komanso Mendulo ya Golide kuchokera ku Pondicherry University chifukwa cha zomwe adachita pamaphunziro ake panthawi ya maphunziro ake a Master. Kafukufuku wake wafalitsidwa m'magazini omwe amawunikidwa ndi anzawo kwambiri kuphatikiza PLOS Neglected Tropical Diseases and Systems Biology. Akamalephera kugwira ntchito komanso kulemba, Hugo amadya kwambiri anime ndi nthabwala, amalemba ndikulemba nyimbo pa gitala ya bass, amadula nyimbo pa MTB, amasewera masewera apakanema (amakonda mawu oti "masewera"), kapena kusintha ukadaulo uliwonse.
Francisco de Souza, Hugo. (Julayi 9, 2023). Kusakaniza kwapadera kwa zotulutsa zomera kumapereka ubwino wamphamvu wotsutsana ndi ziphuphu. Nkhani - Zachipatala. Yatengedwa pa Seputembala 11, 2023, kuchokera ku https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. "Kusakaniza kwapadera kwa zotulutsa za zomera zomwe zili ndi mphamvu zamphamvu zotsutsana ndi ziphuphu." Nkhani - Zachipatala. Seputembala 11, 2023.
Francisco de Souza, Hugo. "Kusakaniza kwapadera kwa zotulutsa za zomera zomwe zili ndi mphamvu zotsutsana ndi ziphuphu." Nkhani - Zachipatala. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Yapezeka pa Seputembala 11, 2023).
Francisco de Souza, Hugo. 2023. Kusakaniza kwapadera kwa zotulutsa za zomera zomwe zili ndi mphamvu zotsutsana ndi ziphuphu. News Medical, yopezeka pa Seputembala 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
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