Zikopa ndi njere za mphesa ndi zipatso zimakhala ndi resveratrol, zomwe zimapangitsa vinyo wofiira kukhala wolemera mu chigawochi. Kafukufuku akuwonetsa kuti ili ndi thanzi labwino, koma muyenera kudziwa zambiri za kuchuluka kwa zowonjezera zomwe muyenera kutenga.
Ngati munamvapo kuti vinyo wofiira amathandizira kuchepetsa mafuta m'thupi, ndiye kuti mwina mudamvapo za resveratrol, chomera chomwe chimapezeka mu vinyo wofiira.
Koma kuwonjezera pa kukhala gawo lopindulitsa la vinyo wofiira ndi zakudya zina, resveratrol imakhalanso ndi thanzi labwino.
M'malo mwake, zowonjezera za resveratrol zimalumikizidwa ndi maubwino ambiri azaumoyo, kuphatikiza kuteteza ntchito zaubongo ndikuchepetsa kuthamanga kwa magazi (1, 2, 3, 4).
Nkhaniyi ikufotokoza zomwe muyenera kudziwa za resveratrol, kuphatikiza mapindu ake asanu ndi awiri apamwamba azaumoyo.
Resveratrol ndi chomera chomwe chimagwira ntchito ngati antioxidant. Zakudya zazikulu ndi vinyo wofiira, mphesa, zipatso, ndi mtedza (5, 6).
Pagululi amakonda kuyika mu zikopa ndi mbewu za mphesa ndi zipatso. Mbali za mphesa izi zimakhudzidwa ndi kuwira kwa vinyo wofiira motero zimakhala ndi resveratrol wambiri (5, 7).
Komabe, maphunziro ambiri a resveratrol achitika mu nyama komanso m'machubu oyesera pogwiritsa ntchito kuchuluka kwa mankhwalawa (5, 8).
Mwa maphunziro ochepa mwa anthu, ambiri amayang'ana kwambiri pamitundu yowonjezereka yapawiri, yomwe imapezeka kwambiri kuposa yomwe imapezeka kuchokera ku chakudya (5).
Resveratrol ndi antioxidant pawiri yomwe imapezeka mu vinyo wofiira, zipatso ndi mtedza. Kafukufuku wambiri wa anthu agwiritsa ntchito zowonjezera zomwe zimakhala ndi resveratrol yambiri.
Chifukwa cha antioxidant katundu, resveratrol ikhoza kukhala chowonjezera chothandizira kuchepetsa kuthamanga kwa magazi (9).
Ndemanga ya 2015 inatsimikizira kuti mlingo waukulu ungathandize kuchepetsa kupsinjika kwa makoma a mitsempha pamene mtima ukugunda (3).
Kuthamanga kumeneku kumatchedwa systolic blood pressure ndipo kumawoneka ngati nambala yokwera kwambiri powerengera kuthamanga kwa magazi.
Kuthamanga kwa magazi kwa systolic nthawi zambiri kumawonjezeka ndi zaka chifukwa cha atherosulinosis. Zikakhala zapamwamba, ndizowopsa kwa matenda amtima.
Resveratrol imatha kuchepetsa kuthamanga kwa magazi pothandizira kupanga nitric oxide yambiri, yomwe imapangitsa kuti mitsempha ya magazi ikhale yopumula (10, 11).
Komabe, olemba kafukufukuyo adati kafukufuku wochulukirapo akufunika kuti apange malingaliro enieni pa mlingo woyenera wa resveratrol kuti ukhale ndi zotsatira zazikulu pa kuthamanga kwa magazi.
Kafukufuku wambiri wa nyama awonetsa kuti zowonjezera za resveratrol zimatha kusintha lipids m'magazi m'njira zathanzi (12, 13).
Mu kafukufuku wa 2016, mbewa zidadyetsedwa zakudya zokhala ndi mapuloteni ambiri komanso mafuta a polyunsaturated ophatikizidwa ndi resveratrol.
Ofufuzawo adapeza kuti pafupifupi kuchuluka kwa cholesterol ndi kulemera kwa mbewa kunatsika, pomwe mulingo wa "zabwino" wa HDL cholesterol ukuwonjezeka (13).
Resveratrol ikuwoneka kuti imakhudza kuchuluka kwa cholesterol pakuchepetsa zochita za michere yomwe imayang'anira kupanga cholesterol (13).
Monga antioxidant, imachepetsanso makutidwe ndi okosijeni a cholesterol "yoyipa" ya LDL. Oxidation ya LDL imatsogolera kupanga zolembera pakhoma la arterial (9, 14).
Pambuyo pa chithandizo cha miyezi isanu ndi umodzi, omwe adatenga mphesa yosakhazikika kapena placebo adatsika ndi 4.5% mu LDL ndi 20% kutsika kwa LDL oxidized (15).
Zowonjezera za resveratrol zitha kupititsa patsogolo kuchuluka kwa lipid m'magazi mwa nyama. Pokhala antioxidant, amachepetsanso oxidation ya LDL cholesterol.
Kuthekera kwa gululi kukulitsa moyo wa zamoyo zosiyanasiyana kwakhala gawo lalikulu la kafukufuku (16).
Pali umboni wosonyeza kuti resveratrol imayambitsa majini ena, potero kupewa matenda okalamba (17).
Izi zimagwira ntchito mofanana ndi kuletsa kwa calorie, zomwe zasonyeza zotsatira zabwino pakuwonjezeka kwa moyo mwa kusintha momwe majini amasonyezera (18, 19).
Ndemanga ya kafukufuku wowunika ulalowu idapeza kuti resveratrol imatalikitsa moyo mu 60% ya zamoyo zomwe zidaphunziridwa, koma zotsatira zake zidadziwika kwambiri zamoyo zomwe sizikugwirizana kwambiri ndi anthu, monga nyongolotsi ndi nsomba (20).
Kafukufuku wa zinyama awonetsa kuti zowonjezera za resveratrol zimatha kukulitsa moyo. Komabe, sizikudziwika ngati iwo adzakhala ndi zotsatira zofanana ndi anthu.
Kafukufuku angapo awonetsa kuti kumwa vinyo wofiira kungathandize kuchepetsa chidziwitso chokhudzana ndi ukalamba (21, 22, 23, 24).
Zikuwoneka kuti zimasokoneza tizidutswa ta mapuloteni otchedwa amyloid beta, omwe ndi ofunikira kwambiri pakupanga mapangidwe amtundu wa matenda a Alzheimer's (21, 25).
Ngakhale kafukufukuyu ndi wosangalatsa, asayansi akadali ndi mafunso okhudzana ndi kuthekera kwa thupi kugwiritsa ntchito resveratrol yowonjezera, kuchepetsa kugwiritsidwa ntchito kwake ngati chowonjezera choteteza ubongo (1, 2).
Resveratrol ndi antioxidant wamphamvu komanso anti-yotupa pawiri yomwe imatha kuteteza ma cell aubongo kuti asawonongeke.
Zopindulitsa izi zikuphatikiza kuwongolera chidwi cha insulin komanso kupewa zovuta za matenda ashuga (26,27,28,29).
Kufotokozera kumodzi kwa momwe resveratrol imagwirira ntchito ndikuti imatha kuletsa enzyme kuti isasinthe shuga kukhala sorbitol, mowa wa shuga.
Sorbitol ikachuluka m'matupi a anthu odwala matenda ashuga, imatha kuyambitsa kupsinjika kwa ma cell (30, 31).
Resveratrol imatha kupindulitsanso odwala matenda ashuga kuposa omwe alibe matenda a shuga. Pakafukufuku wina wa nyama, vinyo wofiira ndi resveratrol adapezeka kuti ali ndi antioxidant wamphamvu mu mbewa za matenda ashuga kuposa mbewa zopanda matenda a shuga (32).
Ofufuza akuti mankhwalawa atha kugwiritsidwa ntchito pochiza matenda a shuga komanso zovuta zake mtsogolo, koma kafukufuku wochulukirapo akufunika.
Resveratrol imathandizira mbewa kukulitsa chidwi cha insulin komanso kuthana ndi zovuta za shuga. M'tsogolomu, odwala matenda ashuga atha kupindulanso ndi chithandizo cha resveratrol.
Mankhwala owonjezera a zitsamba akuphunziridwa ngati njira yochizira ndi kupewa kupweteka kwa mafupa. Ikatengedwa ngati chowonjezera, resveratrol imatha kuteteza chichereŵechereŵe kuti chisawonongeke (33, 34).
Kafukufuku wina adabaya jekeseni wa resveratrol m'mawondo a akalulu a nyamakazi ndipo adapeza kuti akaluluwa anali ndi kuwonongeka kocheperako kwa chichereŵedwe (34).
Kafukufuku wina wamachubu ndi nyama awonetsa kuthekera kwa mankhwalawa kuchepetsa kutupa ndikuletsa kuwonongeka kwamagulu (33, 35, 36, 37).
Resveratrol yaphunziridwa chifukwa cha kuthekera kwake kupewa ndi kuchiza khansa, makamaka m'machubu oyesera. Komabe, zotsatira zasakanizidwa (30, 38, 39).
Zawonetsedwa kuti zimalimbana ndi ma cell a khansa m'maphunziro amtundu wa nyama ndi mayeso, kuphatikiza m'mimba, m'matumbo, pakhungu, m'mawere, ndi khansa ya prostate (40, 41, 42, 43, 44).
Komabe, popeza maphunzirowa mpaka pano achitika m'machubu oyesera ndi nyama, kafukufuku wochulukirapo akufunika kuti amvetsetse ngati komanso momwe mankhwalawa angagwiritsidwe ntchito pochiza khansa mwa anthu.
Kafukufuku wogwiritsa ntchito zowonjezera za resveratrol sanapeze zoopsa zazikulu. Amawoneka kuti amalekerera bwino ndi anthu athanzi (47).
Komabe, ziyenera kudziwidwa kuti pakadali pano palibe malingaliro otsimikizika okhudza kuchuluka kwa resveratrol yomwe munthu ayenera kutenga kuti apeze phindu laumoyo.
Palinso machenjezo, makamaka okhudza momwe resveratrol imagwirira ntchito ndi mankhwala ena.
Chifukwa chakuti mlingo waukulu wasonyezedwa kuti ulepheretse kutsekeka kwa magazi m'machubu oyesera, amatha kuonjezera magazi kapena mabala akamatengedwa ndi anticoagulants monga heparin kapena warfarin, kapena mankhwala ena opweteka (48, 49).
Resveratrol imalepheretsanso ma enzymes omwe amathandiza kuchotsa zinthu zina m'thupi. Izi zikutanthauza kuti mankhwala ena amatha kufika pamlingo wosatetezeka. Izi zikuphatikizapo mankhwala ochepetsa kuthamanga kwa magazi, mankhwala oletsa nkhawa, ndi immunosuppressants (50).
Ngati panopa mukumwa mankhwala, mungafune kulankhula ndi dokotala musanatenge resveratrol.