Khansara ya m'mapapo ndi khansa yachiwiri yofala kwambiri padziko lonse lapansi. Mu 2020, anthu opitilira 2.2 miliyoni padziko lonse lapansi adzapezeka ndi khansa ya m'mapapo koyamba. M’chaka chomwecho, anthu pafupifupi 1.8 miliyoni padziko lonse anafa ndi khansa ya m’mapapo.
Ngakhale pakali pano palibe mankhwala a khansa ya m’mapapo, asayansi akuyesetsa kupeza njira zochizira. Ena mwa asayansiwa amagwira ntchito ku University of Technology Sydney (UTS), komwe kafukufuku watsopano wasonyeza kuti chomera chachilengedwe chotchedwa berberine chingalepheretse kukula kwa maselo a khansa ya m'mapapo mu labotale.
Berberine ndi chomera chomwe chimapezeka mwachilengedwe chomwe chakhala chikugwiritsidwa ntchito muzamankhwala achi China kwazaka masauzande ambiri. Amapezeka muzomera zosiyanasiyana, kuphatikizapo barberry, goldenseal, mphesa ya Oregon, ndi mtengo wa turmeric.

(Chinthu chathu ndiBerberine Extract, olandilidwa moona mtima kufunsa.)

Kafukufuku wazaka zambiri awonetsa kuti berberine ndiyothandiza pothandiza anthu omwe ali ndi matenda amtundu wa 2 kuti azitha kuyendetsa shuga wawo m'magazi ndipo atha kuthandiza kuchiza matenda a metabolic.
Ofufuza apezanso kuti berberine ingagwiritsidwe ntchito pochiza khansa zosiyanasiyana, kuphatikizapo khansa ya ovarian, m'mimba, ndi m'mawere.
Malinga ndi Dr. Kamal Dua, Mphunzitsi wamkulu ndi Senior Research Fellow mu Pharmacy ku Australian Research Center for Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney (UTS) School of Medicine ndi wolemba wamkulu wa phunziroli, Berberine amaletsa makiyi awiri. Njira zakukula kwa khansa - Kuchulukitsa ndi kusamuka kwa ma cell.
Mwamakina, izi zitha kutheka poletsa ma gene ofunikira monga P53, PTEN ndi KRT18 ndi mapuloteni monga AXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. ndi CAPG yokhudzana ndi kuchulukana ndi kusamuka kwa maselo a khansa, "adatero.
Pakafukufuku wamakono, gulu lofufuza kuphatikizapo Dr. Dua, Dr. Keshav Raj Paudel, Pulofesa Philip M. Hansbrough ndi Dr. Bikash Manandhar wa UTS, komanso ogwira ntchito ku Malaysian International Medical University ndi Al Qasim University ku Saudi Arabia, adaphunzira momwe berberine ingagwiritsire ntchito chithandizo cha khansa ya m'mapapo.
"Kugwiritsiridwa ntchito kwachipatala kwa berberine kumakhala kochepa chifukwa cha kusungunuka kwake kosasunthika ndi bioavailability," adatero Dr. Dua wa MNT. "Cholinga chachikulu cha phunziroli ndikuwongolera magawo a physicochemical a berberine posintha berberine kukhala makristalo amadzimadzi amadzimadzi ndikuyang'ana momwe angathere mu m'galasi pakhungu pa alveolar epithelial basal cell of human adenocarcinoma A549."
Gulu lofufuza lapanga njira yotsogola yoperekera mankhwala yomwe imayika berberine m'magawo ang'onoang'ono osungunuka komanso owonongeka. Ma nanoparticles amadzimadziwa akhala akugwiritsidwa ntchito pochiza ma cell a khansa ya m'mapapo amunthu mu vitro mu labotale.
Pamapeto pa phunziroli, gululo linapeza kuti berberine inathandiza kuletsa kupanga mitundu yowonjezereka ya okosijeni, mankhwala opweteka omwe amapangidwa ndi maselo ena chifukwa cha kuukira kwa mabakiteriya ndi zochitika zina zovuta zomwe zingawononge maselo.
Kuphatikiza apo, berberine imathandizira kuwongolera majini okhudzana ndi kupsinjika kwa okosijeni ndi kutupa, ndipo imathandizira kuchepetsa kukalamba msanga kwa maselo.
"Tawonetsa kuti, pogwiritsa ntchito njira ya nanotechnological, katundu wa pawiri akhoza kusintha kuti athetse mavuto osiyanasiyana okhudzana ndi kusungunuka, kutengeka kwa ma cellular, ndi chithandizo chamankhwala," adatero Dr. Dua. Anticancer Potential Athu a berberine liquid crystal nanoparticles adawonetsa ntchito yomweyo kasanu mlingo poyerekeza ndi mabuku osindikizidwa, kuwonetsa bwino phindu la nanodrugs. "
Kuti apitirize kuyesa zotsatirazi, Dr. Dua adanena kuti akufuna kugwiritsa ntchito njira yatsopano yofufuzira kuti azichita maphunziro ozama pogwiritsa ntchito zitsanzo za khansa ya m'mapapo ya preclinical.
"Kufufuza kwina kwa pharmacokinetic ndi anticancer kwa berberine nanodrugs m'zitsanzo za nyama mu vivo kungavumbulutse phindu lawo pochiza khansa ya m'mapapo ndikuwasandutsa njira zochiritsira," adatero.
"Tikatsimikizira mphamvu yotsutsa khansa ya berberine nanodrugs m'zitsanzo za zinyama zowonongeka, sitepe yotsatira idzakhala yopita ku mayesero a zachipatala, zomwe takambirana kale ndi makampani angapo a Sydney," adatero Dr. Dua.
Kuonjezera apo, Dr. Dua adanena kuti kuthekera kwa berberine kuteteza kuyambiranso kwa khansa ya m'mapapo kuyenera kutsimikiziridwa: "Ngakhale kuti sitinafufuzebe izi, tikukonzekera kuti tiphunzire m'maphunziro amtsogolo, komanso tikukhulupirira kuti berberine nanoforms idzasonyeza. ntchito yolonjeza. “.
Dr. Osita Onuga, dokotala wa opaleshoni ya thoracic ndi pulofesa wothandizira opaleshoni ya thoracic ku St. John Cancer Institute ku Providence St. John Medical Center ku Santa Monica, California, anauza MNT kuti ofufuza akapeza mipata yatsopano yothandizira ndi kupewa khansa, nthawi zonse pamakhala chiyembekezo:
"Berberine ndi gawo lamankhwala a Kum'mawa, kotero sitigwiritsa ntchito mwamwambo pamankhwala aku Western. Ndikuganiza kuti ndizosangalatsa chifukwa tikuyang'ana zomwe tikudziwa kuti zili ndi zopindulitsa pazamankhwala akum'mawa, ndikuziyika muzofufuza kuti zithandizire kumasulira kumankhwala aku Western. “.
"Zimalonjeza nthawi zonse, koma zili mu labu, ndipo zambiri zomwe timapeza mu labu sizipangitsa kuti odwala azilandira chithandizo," adatero Onuga. "Ndikuganiza kuti chotsatira ndicho kuyesa odwala ndikupeza mlingo."
Anthu ena amakumana ndi zizindikiro zobisika za khansa ya m'mapapo kumayambiriro kwa matendawa. Werengani kuti mudziwe zambiri, kuphatikizapo nthawi yoti muwone dokotala.
Khansara ya m'mapapo imapezeka mosiyanasiyana mwa amayi ndi abambo, koma zizindikiro ndi zowopsa ndizofanana. Apa tikufotokozera zotheka za majini ndi mahomoni…
Ndife akatswiri opanga ufa wopangira ufa, talandiridwa kuti tikutumizireni mafunso aliwonse okhudzana ndi malonda athu ndipo tili ndi anzathu omwe ali ndi udindo kuti athetse mavuto anu okhudza kugulitsa kale komanso kugulitsa. Lumikizanani Nafe Nthawi Iliyonse !!!