Khansa ya m'mapapo ndi mtundu wachiwiri wofala kwambiri wa khansa padziko lonse lapansi. Mu 2020, anthu oposa 2.2 miliyoni padziko lonse lapansi adzapezeka ndi khansa ya m'mapapo koyamba. M'chaka chomwecho, anthu pafupifupi 1.8 miliyoni padziko lonse lapansi adamwalira ndi khansa ya m'mapapo.
Ngakhale pakadali pano palibe mankhwala a khansa ya m'mapapo, asayansi akugwira ntchito yofufuza njira zina zochiritsira. Ena mwa asayansiwa amagwira ntchito ku University of Technology Sydney (UTS), komwe kafukufuku watsopano wasonyeza kuti chomera chachilengedwe chotchedwa berberine chingalepheretse kukula kwa maselo a khansa ya m'mapapo mu labotale.
Berberine ndi chomera chachilengedwe chomwe chakhala chikugwiritsidwa ntchito mu mankhwala achikhalidwe aku China kwa zaka masauzande ambiri. Chimapezeka m'zomera zosiyanasiyana, kuphatikizapo barberry, goldenseal, mphesa za ku Oregon, ndi tree turmeric.

(Katundu wathu ndiChotsitsa cha Berberine, takulandirani moona mtima ku funso.)

Kafukufuku wa zaka zambiri wasonyeza kuti berberine ndi yothandiza pothandiza anthu omwe ali ndi matenda a shuga a mtundu wa 2 kuwongolera kuchuluka kwa shuga m'magazi mwawo ndipo ingathandize kuchiza matenda a metabolic.
Ofufuza apezanso kuti berberine ingagwiritsidwe ntchito pochiza mitundu yosiyanasiyana ya khansa, kuphatikizapo khansa ya mazira, m'mimba, ndi m'mawere.
Malinga ndi Dr. Kamal Dua, Mphunzitsi Wamkulu komanso Mphunzitsi Wamkulu mu Pharmacy ku Australian Research Center for Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney (UTS) School of Medicine komanso wolemba wamkulu wa kafukufukuyu, Berberine imaletsa njira ziwiri zofunika kwambiri pakukula kwa khansa - Kufalikira ndi kusamuka kwa maselo.
"Mwa makina, izi zitha kuchitika mwa kuletsa majini ofunikira monga P53, PTEN ndi KRT18 ndi mapuloteni monga AXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. ndi CAPG yogwirizana ndi kuchulukana ndi kusamuka kwa maselo a khansa," adatero.
Mu kafukufuku waposachedwa, gulu lofufuza kuphatikizapo Dr. Dua, Dr. Keshav Raj Paudel, Pulofesa Philip M. Hansbrough ndi Dr. Bikash Manandhar wa ku UTS, komanso ogwira ntchito ku Malaysian International Medical University ndi Al Qasim University ku Saudi Arabia, adaphunzira momwe berberine ingagwiritsidwire ntchito pochiza khansa ya m'mapapo.
"Kugwiritsa ntchito berberine kuchipatala n'kochepa chifukwa cha kusasungunuka bwino komanso kupezeka kwake," adatero Dr. Dua wa MNT. "Cholinga chachikulu cha kafukufukuyu ndikukonza magawo a fizikiki ya berberine mwa kusintha berberine kukhala tinthu tating'onoting'ono ta kristalo yamadzimadzi ndikufufuza mphamvu yake yolimbana ndi khansa mu vitro pa maselo oyambira a alveolar epithelial a human adenocarcinoma A549."
Gulu lofufuza lapanga njira yapamwamba yoperekera mankhwala yomwe imaphimba berberine m'magawo ang'onoang'ono osungunuka komanso owonongeka. Tinthu tating'onoting'ono ta kristalo tamadzimadzi tagwiritsidwa ntchito pochiza maselo a khansa ya m'mapapo mwa anthu mu labotale.
Kumapeto kwa kafukufukuyu, gululo linapeza kuti berberine inathandiza kuletsa kupanga mitundu ya okosijeni yogwira ntchito, mankhwala otupa opangidwa ndi maselo ena poyankha kuukira kwa mabakiteriya ndi zochitika zina zopsinjika zomwe zingawononge maselo.
Kuphatikiza apo, berberine imathandiza kuwongolera majini okhudzana ndi kupsinjika kwa okosijeni ndi kutupa, komanso kumathandiza kuchepetsa kukalamba msanga kwa maselo.
“Tawonetsa kuti, pogwiritsa ntchito njira ya nanotechnology, makhalidwe a mankhwalawa amatha kukonzedwa kuti athetse mavuto osiyanasiyana okhudzana ndi kusungunuka, kuyamwa kwa maselo, komanso mphamvu ya mankhwala,” anafotokoza Dr. Dua. Kuthekera kwa Khansa Ma nanoparticles athu a berberine liquid crystal adawonetsa ntchito yomweyi pamlingo wowirikiza kasanu poyerekeza ndi mabuku ofalitsidwa, zomwe zikuwonetsa bwino ubwino wa nanodrugs.”
Pofuna kuyesa zotsatira izi, Dr. Dua adati akukonzekera kugwiritsa ntchito njira yatsopano yofufuzira kuti achite kafukufuku wozama pogwiritsa ntchito zitsanzo za nyama zomwe zisanachitike chithandizo cha khansa ya m'mapapo.
"Kafukufuku wowonjezera wa mankhwala ndi mankhwala oletsa khansa wa mankhwala a berberine nanodrugs m'zinyama zomwe zili m'thupi la munthu angasonyeze ubwino wawo pochiza khansa ya m'mapapo ndikuwasandutsa mitundu yochiritsira," adatero.
"Tikatsimikizira kuthekera kwa mankhwala a berberine nanodrugs polimbana ndi khansa m'zitsanzo za nyama zoyembekezera kuchipatala, gawo lotsatira lidzakhala kupita ku mayeso azachipatala, omwe tikukambirana kale ndi makampani angapo aku Sydney," adatero Dr. Dua.
Kuphatikiza apo, Dr. Dua adati kuthekera kwa berberine kuteteza kubwereranso kwa khansa ya m'mapapo kuyenera kutsimikiziridwa: "Ngakhale sitinafufuze izi, tikukonzekera kuziphunzira m'maphunziro amtsogolo, ndipo tikukhulupiriranso kuti ma nanoform a berberine adzawonetsa ntchito yabwino."
Dr. Osita Onuga, dokotala wa opaleshoni ya chifuwa komanso pulofesa wothandizira opaleshoni ya chifuwa ku St. John Cancer Institute ku Providence St. John Medical Center ku Santa Monica, California, adauza MNT kuti ofufuza akapeza mwayi watsopano wochiza ndikuletsa khansa, nthawi zonse pamakhala chiyembekezo:
"Berberine ndi gawo la mankhwala aku Eastern, kotero sitimagwiritsa ntchito mwachizolowezi mu mankhwala aku Western. Ndikuganiza kuti ndizosangalatsa chifukwa tikuyang'ana zomwe tikudziwa kuti zili ndi ubwino pa mankhwala aku Eastern, ndikuziyika mu kafukufuku kuti zithandize kumasulira zimenezo mu mankhwala aku Western."
"Nthawi zonse zimakhala zabwino, koma zimakhala mu labu, ndipo zambiri zomwe timapeza mu labu sizimapangitsa kuti odwala alandire chithandizo," Onuga adapitiliza. "Ndikuganiza kuti chinthu chotsatira choti muchite ndikuchita mayeso azachipatala kwa odwala ndikupeza mlingo wake."
Anthu ena amakumana ndi zizindikiro zosawoneka bwino za khansa ya m'mapapo kumayambiriro kwa matendawa. Pitirizani kuwerenga kuti mudziwe zambiri, kuphatikizapo nthawi yoti mukaonane ndi dokotala.
Khansa ya m'mapapo imachitika mosiyanasiyana mwa akazi ndi amuna, koma zizindikiro ndi zoopsa zake ndi zofanana. Apa tikufotokoza za majini ndi mahomoni omwe angakhalepo…
Ndife akatswiri opanga ufa wochotsa zomera, tikukulandirani kuti tikutumizireni mafunso aliwonse okhudza malonda athu ndipo tili ndi mnzanu wodalirika woti akuthandizeni kuthetsa mavuto anu okhudza kugulitsa musanagulitse komanso mutagulitsa. Lumikizanani nafe nthawi iliyonse!!!