Zina mwazolemba zaposachedwa kwambiri za antioxidant wamphamvuyi ndi ndemanga yomwe idasindikizidwa mu Phytotherapy Research mu Marichi 2019, yomwe idawunikiranso zinthu 9 zokhudzana ndi zotsatira za quercetin pa metabolic syndrome Mayesero oyendetsedwa mwachisawawa.

Metabolic syndrome imatanthawuza mndandanda wamavuto azaumoyo omwe amawonjezera chiopsezo cha matenda a shuga a 2, matenda amtima, ndi sitiroko, kuphatikiza kuthamanga kwa magazi, shuga wambiri, kuchuluka kwa triglyceride, komanso kuchuluka kwamafuta m'chiuno.

Ngakhale kafukufuku wokwanira wapeza kuti quercetin ilibe mphamvu pakusala kudya kwa shuga, insulin kukana kapena hemoglobin A1c milingo, kuwunika kwina kwamagulu ang'onoang'ono kunawonetsa kuti quercetin idawonjezeredwa m'maphunziro omwe amatenga osachepera 500 mg patsiku kwa milungu ingapo eyiti. Kwambiri yafupika kusala kudya shuga.

Quercetin imathandizira kuwongolera ma jini

Malinga ndi kafukufuku yemwe adasindikizidwa mu 2016, quercetin imatha kuyambitsanso njira ya mitochondrial ya apoptosis (maselo opangidwa ndi maselo owonongeka) polumikizana ndi DNA, potero kupangitsa kuti chotupa chiziyenda bwino.

Kafukufuku wapeza kuti quercetin ikhoza kuyambitsa cytotoxicity ya maselo a khansa ya m'magazi, ndipo zotsatira zake zimagwirizana ndi mlingo. Zotsatira zochepa za cytotoxic zapezekanso m'maselo a khansa ya m'mawere. Nthawi zambiri, quercetin imatha kukulitsa moyo wa mbewa za khansa ndi nthawi za 5 poyerekeza ndi gulu lowongolera lomwe silinachiritsidwe.

Olembawo akuti izi zimatheka chifukwa cha kuyanjana kwachindunji pakati pa quercetin ndi DNA komanso kuyambitsa kwake njira ya mitochondrial ya apoptosis, ndipo akuwonetsa kuti kugwiritsa ntchito quercetin ngati mankhwala adjuvant pochiza khansa ndikoyenera kufufuzidwanso.

Kafukufuku waposachedwa wofalitsidwa mu nyuzipepala ya Molecules adatsindikanso za epigenetic za quercetin ndi kuthekera kwake:

Kulumikizana ndi ma cell signing channels
Sinthani mawonekedwe a jini
Zimakhudza ntchito ya zinthu zolembera
Imawongolera microribonucleic acid (microRNA)

Microribonucleic acid nthawi ina idawonedwa ngati DNA "yopanda pake". Kafukufuku wasonyeza kuti DNA “yopanda pake” sichabechabe. Ndi kamolekyu kakang'ono ka ribonucleic acid, kamene kamagwira ntchito yofunika kwambiri pakuwongolera majini omwe amapanga mapuloteni a anthu.

Microribonucleic acid ingagwiritsidwe ntchito ngati "kusintha" kwa majini awa. Malinga ndi kulowetsa kwa microribonucleic acid, jini imatha kubisa chilichonse mwazinthu zopitilira 200 zama protein. Kutha kwa Quercetin kusinthira ma microRNAs kumatha kufotokozeranso zotsatira zake za cytotoxic komanso chifukwa chake zikuwoneka kuti zikuwonjezera kupulumuka kwa khansa (osachepera mbewa).

Quercetin ndi mankhwala amphamvu oletsa ma virus

Monga tafotokozera pamwambapa, kafukufuku wopangidwa mozungulira quercetin amayang'ana kwambiri mphamvu yake yoletsa ma virus, yomwe imachitika makamaka chifukwa cha njira zitatu zochitira:

Kuletsa mphamvu ya ma virus kupatsira ma cell
Iletsa kugawanika kwa maselo omwe ali ndi kachilomboka
Chepetsani kukana kwa maselo omwe ali ndi kachilomboka kumankhwala oletsa ma virus

Mwachitsanzo, kafukufuku yemwe adathandizidwa ndi dipatimenti yachitetezo ku US yomwe idasindikizidwa mu 2007 idapeza kuti mutatha kupsinjika kwambiri, quercetin imatha kuchepetsa chiopsezo chotenga kachilomboka ndikuwongolera magwiridwe antchito amisala, apo ayi ikhoza kuwononga chitetezo chanu chamthupi , Kukupangitsani kukhala otengeka kwambiri. ku matenda.

Pakafukufukuyu, oyendetsa njinga amalandila 1000 mg wa quercetin patsiku, kuphatikiza ndi vitamini C (kuchulukitsa kwa plasma quercetin) ndi niacin (kupititsa patsogolo kuyamwa) kwa milungu isanu yotsatizana. Zotsatirazo zinapeza kuti poyerekeza ndi osalandira chithandizo Kwa woyendetsa njinga aliyense amene analandira chithandizo, amene anatenga quercetin anali ndi mwayi wochepa kwambiri wotenga matenda a tizilombo akamakwera njinga kwa maola atatu pa tsiku kwa masiku atatu otsatizana. 45% ya anthu omwe ali m'gulu la placebo anali kudwala, pomwe 5% yokha ya anthu omwe anali mgulu lachipatala anali kudwala.

Bungwe la US Defense Advanced Research Projects Agency (DARPA) lapereka ndalama pa kafukufuku wina, womwe unasindikizidwa mu 2008, ndipo adaphunzira kugwiritsa ntchito kachilombo koyambitsa matenda a chimfine cha H1N1 kutsutsa zinyama zothandizidwa ndi quercetin. Chotsatiracho chikadali chofanana, kudwala ndi kufa kwa gulu lachipatala kunali kochepa kwambiri kuposa gulu la placebo. Kafukufuku wina watsimikiziranso mphamvu ya quercetin motsutsana ndi ma virus osiyanasiyana, kuphatikiza:

Kafukufuku mu 1985 adapeza kuti quercetin imatha kuletsa matenda ndi kubwerezabwereza kwa kachilombo ka herpes simplex mtundu 1, poliovirus mtundu 1, parainfluenza virus mtundu 3, ndi kupuma syncytial virus.

Kafukufuku wa nyama mu 2010 adapeza kuti quercetin imatha kuletsa ma virus onse a chimfine A ndi B. Palinso zinthu ziwiri zazikulu zomwe zapezedwa. Choyamba, mavairasiwa sangathe kukana quercetin; chachiwiri, ngati agwiritsidwa ntchito limodzi ndi mankhwala oletsa tizilombo toyambitsa matenda (amantadine kapena oseltamivir), zotsatira zake zimakhala zowonjezereka-ndipo chitukuko cha kukana chimalephereka.

Kafukufuku wa nyama mu 2004 adavomereza zamtundu wa kachilombo ka H3N2, pofufuza momwe quercetin imakhudzira chimfine. Wolembayo ananena kuti:

"Panthawi ya matenda a fuluwenza, kupsinjika kwa okosijeni kumachitika. Chifukwa quercetin imatha kubwezeretsanso kuchuluka kwa ma antioxidants ambiri, anthu ena amaganiza kuti ikhoza kukhala mankhwala othandiza omwe angateteze mapapu kuti asatulutsidwe panthawi ya kachilombo ka fuluwenza. Zotsatira zoyipa za ma radicals opanda okosijeni. "

Kafukufuku wina wa 2016 adapeza kuti quercetin imatha kuwongolera mawonekedwe a mapuloteni ndipo imakhala ndi chitetezo pa kachilombo ka fuluwenza ya H1N1. Makamaka, kuwongolera kwa mapuloteni owopsa a kutentha, fibronectin 1 ndi mapuloteni oletsa kumathandizira kuchepetsa kufalikira kwa kachilomboka.

Kafukufuku wachitatu yemwe adasindikizidwa mu 2016 adapeza kuti quercetin imatha kuletsa mitundu yosiyanasiyana ya chimfine, kuphatikiza H1N1, H3N2, ndi H5N1. Wolemba lipoti la kafukufukuyu akukhulupirira kuti, "Kafukufukuyu akuwonetsa kuti quercetin imawonetsa zoletsa kumayambiriro kwa matenda a chimfine, zomwe zimapereka dongosolo lotheka la chithandizo chamtsogolo kudzera pakupanga mankhwala achilengedwe ogwira ntchito, otetezeka, komanso otsika mtengo ochizira ndi kupewa [Fuluwenza. A virus] matenda."

Mu 2014, ofufuza adawonetsa kuti quercetin "ikuwoneka kuti ikulonjeza kuchiza chimfine chomwe chimayambitsidwa ndi ma rhinoviruses" ndikuwonjezera kuti, "Kafukufuku watsimikizira kuti quercetin imatha kuchepetsa kulowetsedwa kwamkati ndi kubwereza kwa ma virus mu vitro. Thupi limatha kuchepetsa kuchuluka kwa ma virus, chibayo komanso kuyankha panjira ya mpweya."

Quercetin amathanso kuchepetsa kuwonongeka kwa okosijeni, potero kuchepetsa chiopsezo cha matenda achiwiri a bakiteriya, omwe ndi omwe amachititsa imfa zokhudzana ndi chimfine. Chofunika kwambiri, quercetin imachulukitsa mitochondrial biosynthesis mu minofu ya chigoba, zomwe zikuwonetsa kuti gawo lina la antivayirasi limakhala chifukwa champhamvu ya antiviral ya mitochondrial.

Kafukufuku wa nyama mu 2016 adapeza kuti quercetin imatha kuletsa kachilombo ka dengue komanso matenda a hepatitis mu mbewa. Kafukufuku wina watsimikiziranso kuti quercetin imatha kuletsa matenda a hepatitis B ndi C.

Posachedwapa, kafukufuku yemwe adasindikizidwa mu nyuzipepala ya Microbial Pathogenesis mu Marichi 2020 adapeza kuti quercetin imatha kupereka chitetezo chokwanira ku matenda a Streptococcus pneumoniae mu vitro komanso mu vivo. Poizoni (PLY) yotulutsidwa ndi pneumococcus kuteteza kufalikira kwa matenda a Streptococcus pneumoniae. Mu lipoti la "Microbial Pathogenesis", wolemba adati:

"Zotsatirazi zikuwonetsa kuti quercetin imachepetsa kwambiri ntchito ya hemolytic ndi cytotoxicity yoyambitsidwa ndi PLY poletsa mapangidwe a oligomers.
Kuonjezera apo, chithandizo cha quercetin chingathenso kuchepetsa kuwonongeka kwa maselo a PLY, kuonjezera kuchuluka kwa mbewa zomwe zili ndi mlingo wakupha wa Streptococcus pneumoniae, kuchepetsa kuwonongeka kwa mapapo, ndikuletsa ma cytokines (IL-1β ndi TNF) mu bronchoalveolar lavage fluid. -α) kumasulidwa.
Poganizira za kufunika kwa zochitikazi mu matenda a Streptococcus pneumoniae osamva, zotsatira zathu zimasonyeza kuti quercetin ikhoza kukhala mankhwala atsopano ochiritsira matenda a pneumococcal. "
Quercetin imalimbana ndi kutupa ndikuwonjezera chitetezo chamthupi

Kuphatikiza pa antivayirasi, quercetin imathanso kukulitsa chitetezo chokwanira komanso kuthana ndi kutupa. Kafukufuku wa 2016 wofalitsidwa mu nyuzipepala ya Nutrients adawonetsa kuti njira zogwirira ntchito zimaphatikizapo (koma sizimangokhala) kuletsa kwa:

• Tumor necrosis factor alpha (TNF-α) yopangidwa ndi lipopolysaccharide (LPS) mu macrophages. TNF-α ndi cytokine yomwe imakhudzidwa ndi kutupa kwadongosolo. Imatulutsidwa ndi macrophages omwe adatsegulidwa. Macrophages ndi maselo a chitetezo cha mthupi omwe amatha kumeza zinthu zakunja, tizilombo toyambitsa matenda ndi zinthu zina zovulaza kapena zowonongeka.
• Lipopolysaccharide-induced TNF-α ndi interleukin (Il) -1α mRNA milingo m'maselo a glial, zomwe zingayambitse "kuchepa kwa neuronal cell apoptosis"
• Kuletsa kupanga ma enzyme oyambitsa kutupa
• Kuletsa calcium kuti isalowe m'maselo, potero kulepheretsa:
◦ Kutulutsidwa kwa ma cytokines oyambitsa kutupa
◦ Maselo a m'mimba amatulutsa histamine ndi serotonin 

Malinga ndi nkhaniyi, quercetin angathenso kukhazikika mast maselo, ali cytoprotective ntchito pa m`mimba thirakiti, ndipo "ali ndi malangizo mwachindunji pa zofunika zinchito makhalidwe a chitetezo cha m'thupi", kotero kuti akhoza "pansi-kulamulira kapena ziletsa zosiyanasiyana za njira zotupa ndi ntchito," Imalepheretsa kuchuluka kwazomwe timayang'ana ma cell mumtundu wa ma micromolar ".

Quercetin ikhoza kukhala yothandiza kwa anthu ambiri

Poganizira za ubwino wambiri wa quercetin, ukhoza kukhala wowonjezera wopindulitsa kwa anthu ambiri, kaya ndizovuta kapena zovuta za nthawi yayitali, zimatha kukhala ndi zotsatira zina. Izi ndizowonjezera zomwe ndikupangira kuti muzisunga mu kabati yamankhwala. Zingakhale zothandiza pamene mukumva kuti mwatsala pang'ono "kuthedwa nzeru" ndi vuto la thanzi (kaya ndi chimfine kapena chimfine).

Ngati mumakonda kugwidwa ndi chimfine ndi chimfine, mungaganizire kumwa quercetin miyezi ingapo nyengo yozizira isanafike komanso chimfine kuti mulimbikitse chitetezo chamthupi. M'kupita kwanthawi, zikuwoneka kuti ndizothandiza kwambiri kwa odwala omwe ali ndi vuto la metabolic, koma ndizopusa kwambiri kudalira zowonjezera zina ndikulephera kuthana ndi zovuta zazikulu monga zakudya ndi masewera olimbitsa thupi nthawi imodzi.