Pakati pa mapepala aposachedwa okhudza antioxidant wamphamvu iyi pali ndemanga yofalitsidwa mu Phytotherapy Research mu Marichi 2019, yomwe idawunikiranso zinthu 9 zokhudza zotsatira za quercetin pa matenda a metabolic. Mayeso olamulidwa mwachisawawa.

Matenda a kagayidwe kachakudya amatanthauza mavuto angapo azaumoyo omwe amawonjezera chiopsezo cha matenda a shuga amtundu wachiwiri, matenda a mtima, ndi sitiroko, kuphatikizapo kuthamanga kwa magazi, shuga wambiri m'magazi, kuchuluka kwa triglyceride m'magazi, komanso kuchuluka kwa mafuta m'chiuno.

Ngakhale kuti kafukufuku wokwanira wapeza kuti quercetin siikhudza shuga m'magazi osadya, kukana insulin kapena kuchuluka kwa hemoglobin A1c, kusanthula kwina kwa magulu ang'onoang'ono kunawonetsa kuti quercetin idawonjezeredwa m'maphunziro omwe adatenga osachepera 500 mg patsiku kwa milungu yosachepera eyiti.

Quercetin imathandiza kulamulira kagayidwe ka majini

Malinga ndi kafukufuku wofalitsidwa mu 2016, quercetin imatha kuyambitsa njira ya mitochondrial ya apoptosis (kufa kwa maselo owonongeka) mwa kuyanjana ndi DNA, zomwe zimapangitsa kuti chotupa chibwerere m'mbuyo.

Kafukufuku wapeza kuti quercetin ikhoza kuyambitsa poizoni m'maselo a khansa ya m'magazi, ndipo zotsatira zake zimagwirizana ndi mlingo. Zotsatira zochepa za poizoni m'maselo zapezekanso m'maselo a khansa ya m'mawere. Kawirikawiri, quercetin imatha kukulitsa moyo wa mbewa za khansa ndi nthawi 5 poyerekeza ndi gulu loyang'anira lomwe silinalandire chithandizo.

Olembawo amati zotsatirazi zimachitika chifukwa cha kugwirizana kwa quercetin ndi DNA komanso kuyambitsa kwake njira ya mitochondrial ya apoptosis, ndipo akunena kuti kugwiritsa ntchito quercetin ngati mankhwala othandizira pochiza khansa ndikofunikira kufufuza kwina.

Kafukufuku waposachedwa wofalitsidwa mu magazini ya Molecules adagogomezeranso za zotsatira za epigenetic za quercetin ndi kuthekera kwake kochita izi:

Kuyanjana ndi njira zolumikizirana ndi ma cell
Yang'anirani momwe majini amagwirira ntchito
Kukhudza ntchito ya zinthu zolembera
Amayang'anira microribonucleic acid (microRNA)

Kalelo, asidi ya microribonucleic inkaonedwa ngati DNA "yopanda ntchito". Kafukufuku wapeza kuti DNA "yopanda ntchito" si yopanda ntchito. Ndi molekyulu yaying'ono ya ribonucleic acid, yomwe imagwira ntchito yofunika kwambiri pakulamulira majini omwe amapanga mapuloteni a anthu.

Microribonucleic acid ingagwiritsidwe ntchito ngati "kusintha" kwa majini awa. Malinga ndi zomwe microribonucleic acid imalowetsa, jini imatha kupanga chilichonse mwa zinthu zoposa 200 za mapuloteni. Kutha kwa Quercetin kusintha ma microRNA kungathenso kufotokoza zotsatira zake za poizoni komanso chifukwa chake zikuwoneka kuti zimawonjezera kupulumuka khansa (makamaka kwa mbewa).

Quercetin ndi mankhwala amphamvu oletsa mavairasi

Monga tafotokozera pamwambapa, kafukufuku wochitidwa wokhudza quercetin akuyang'ana kwambiri mphamvu yake yolimbana ndi mavairasi, zomwe zimachitika makamaka chifukwa cha njira zitatu zogwirira ntchito:

Kuletsa mphamvu ya mavairasi yopatsira maselo
Letsani kuchulukitsa kwa maselo omwe ali ndi kachilomboka
Kuchepetsa kukana kwa maselo omwe ali ndi kachilombo ku chithandizo cha mankhwala oletsa mavairasi

Mwachitsanzo, kafukufuku wothandizidwa ndi Unduna wa Zachitetezo ku US womwe unasindikizidwa mu 2007 unapeza kuti mukakumana ndi nkhawa yayikulu, quercetin imatha kuchepetsa chiopsezo chanu chotenga kachilomboka ndikuwonjezera magwiridwe antchito amisala, apo ayi ingawononge chitetezo chanu cha mthupi, zomwe zingakupangitseni kukhala pachiwopsezo chachikulu cha matenda.

Mu kafukufukuyu, okwera njinga adalandira 1000 mg ya quercetin patsiku, kuphatikiza ndi vitamini C (kuwonjezera kuchuluka kwa quercetin m'magazi) ndi niacin (kulimbikitsa kuyamwa) kwa milungu isanu yotsatizana. Zotsatira zake zapeza kuti poyerekeza ndi osachiritsidwa. Kwa wokwera njinga aliyense amene adalandira chithandizo, omwe adamwa quercetin anali ndi mwayi wochepa kwambiri wopeza matenda opatsirana ndi mavairasi atakwera njinga kwa maola atatu patsiku kwa masiku atatu otsatizana. 45% ya anthu omwe adapatsidwa placebo anali odwala, pomwe 5% yokha ya anthu omwe adapatsidwa chithandizo anali odwala.

Bungwe la US Defense Advanced Research Projects Agency (DARPA) lapereka ndalama ku kafukufuku wina, womwe unasindikizidwa mu 2008, ndipo linaphunzira za kugwiritsa ntchito kachilombo ka H1N1 komwe kamayambitsa matenda ambiri polimbana ndi nyama zomwe zimalandira chithandizo cha quercetin. Zotsatira zake zikadali chimodzimodzi, matenda ndi imfa za gulu lolandira chithandizo zinali zochepa kwambiri kuposa za gulu la placebo. Maphunziro ena atsimikiziranso kuti quercetin imagwira ntchito bwino polimbana ndi mavairasi osiyanasiyana, kuphatikizapo:

Kafukufuku wina mu 1985 adapeza kuti quercetin imatha kuletsa matenda ndi kubwerezabwereza kwa kachilombo ka herpes simplex mtundu 1, kachilombo ka polio mtundu 1, kachilombo ka parainfluenza mtundu 3, ndi kachilombo koyambitsa matenda a respiratory syncytial.

Kafukufuku wa nyama mu 2010 adapeza kuti quercetin imatha kuletsa mavairasi onse a chimfine A ndi B. Palinso zinthu ziwiri zazikulu zomwe zapezeka. Choyamba, mavairasi awa sangapange kukana kwa quercetin; chachiwiri, ngati agwiritsidwa ntchito limodzi ndi mankhwala oletsa mavairasi (amantadine kapena oseltamivir), zotsatira zake zimawonjezeka kwambiri - ndipo kukana kwa matendawa kumapewedwa.

Kafukufuku wa nyama mu 2004 adavomereza mtundu wa kachilombo ka H3N2, kufufuza momwe quercetin imakhudzira chimfine. Wolembayo adati:

"Pa nthawi ya matenda a chimfine, kupsinjika kwa okosijeni kumachitika. Chifukwa quercetin imatha kubwezeretsa kuchuluka kwa ma antioxidants ambiri, anthu ena amaganiza kuti ikhoza kukhala mankhwala othandiza omwe angateteze mapapo kuti asatuluke panthawi ya matenda a chimfine. Zotsatirapo zoyipa za ma free radicals a oxygen."

Kafukufuku wina wa mu 2016 adapeza kuti quercetin imatha kulamulira kuchuluka kwa mapuloteni ndipo imateteza kachilombo ka H1N1 fuluwenza. Makamaka, kulamulira mapuloteni owopsa a kutentha, fibronectin 1 ndi mapuloteni oletsa kumathandiza kuchepetsa kuchulukitsa kwa kachilomboka.

Kafukufuku wachitatu wofalitsidwa mu 2016 adapeza kuti quercetin imatha kuletsa mitundu yosiyanasiyana ya chimfine, kuphatikizapo H1N1, H3N2, ndi H5N1. Wolemba lipoti la kafukufukuyu akukhulupirira kuti, "Kafukufukuyu akuwonetsa kuti quercetin imagwira ntchito yoletsa matenda a chimfine kumayambiriro kwa matendawa, zomwe zimapereka dongosolo lothandizira mtsogolo kudzera mukupanga mankhwala achilengedwe ogwira mtima, otetezeka, komanso otsika mtengo ochizira ndikuletsa matenda a [Influenza A virus]."

Mu 2014, ofufuza adanena kuti quercetin "ikuwoneka yothandiza pochiza chimfine choyambitsidwa ndi ma rhinovirus" ndipo adawonjezera kuti, "Kafukufuku watsimikizira kuti quercetin imatha kuchepetsa kulowa mkati ndi kubwerezabwereza kwa mavairasi mu vitro. Thupi limatha kuchepetsa kuchuluka kwa mavairasi, chibayo ndi kuyankha mopitirira muyeso kwa mpweya."

Quercetin ingachepetsenso kuwonongeka kwa okosijeni, motero imachepetsa chiopsezo cha matenda ena achiwiri a bakiteriya, omwe ndi omwe amachititsa imfa zokhudzana ndi chimfine. Chofunika kwambiri, quercetin imawonjezera kupanga kwa mitochondrial m'minofu ya mafupa, zomwe zikusonyeza kuti gawo lina la mphamvu yake yolimbana ndi mavairasi ndi chifukwa cha chizindikiro chowonjezera cha mavairasi a mitochondrial.

Kafukufuku wa nyama mu 2016 adapeza kuti quercetin imatha kuletsa kachilombo ka dengue ndi kachilombo ka hepatitis m'makoswe. Kafukufuku wina watsimikiziranso kuti quercetin imatha kuletsa matenda a hepatitis B ndi C.

Posachedwapa, kafukufuku wofalitsidwa mu magazini ya Microbial Pathogenesis mu Marichi 2020 adapeza kuti quercetin imatha kupereka chitetezo chokwanira ku matenda a Streptococcus pneumoniae m'thupi komanso m'thupi. Poizoni (PLY) wotulutsidwa ndi pneumococcus kuti apewe kufalikira kwa matenda a Streptococcus pneumoniae. Mu lipoti la "Microbial Pathogenesis", wolembayo adati:

"Zotsatira zake zikusonyeza kuti quercetin imachepetsa kwambiri ntchito ya hemolytic ndi cytotoxicity yomwe imabwera chifukwa cha PLY mwa kuletsa kupangika kwa oligomers."
Kuphatikiza apo, chithandizo cha quercetin chingachepetsenso kuwonongeka kwa maselo komwe kumayambitsidwa ndi PLY, kuwonjezera kuchuluka kwa kupulumuka kwa mbewa zomwe zili ndi Streptococcus pneumoniae yoopsa, kuchepetsa kuwonongeka kwa mapapo, ndikuletsa ma cytokines (IL-1β ndi TNF) mu bronchoalveolar lavage fluid. -α).
Poganizira kufunika kwa zochitikazi pakukula kwa matenda a Streptococcus pneumoniae osagonja, zotsatira zathu zikusonyeza kuti quercetin ikhoza kukhala mankhwala atsopano omwe angagwiritsidwe ntchito pochiza matenda opatsirana a pneumococcal.
Quercetin imalimbana ndi kutupa komanso imalimbitsa chitetezo chamthupi

Kuwonjezera pa mphamvu yake yoletsa mavairasi, quercetin imathanso kuwonjezera chitetezo cha mthupi komanso kulimbana ndi kutupa. Kafukufuku wa 2016 wofalitsidwa mu magazini ya Nutrients adawonetsa kuti njira zomwe zimagwiritsidwa ntchito zimaphatikizapo (koma sizimangokhala) kuletsa:

• Chotupa cha tumor necrosis factor alpha (TNF-α) chomwe chimayamba chifukwa cha lipopolysaccharide (LPS) m'ma macrophages. TNF-α ndi cytokine yomwe imagwira ntchito pa kutupa kwa thupi. Imatulutsidwa ndi ma macrophages omwe amagwira ntchito. Ma macrophages ndi maselo oteteza thupi omwe amatha kumeza zinthu zakunja, tizilombo toyambitsa matenda ndi zinthu zina zoopsa kapena zowonongeka.
• Kuchuluka kwa TNF-α ndi interleukin (Il)-1α mRNA komwe kumayambitsa lipopolysaccharide m'maselo a glial, zomwe zingayambitse "kuchepa kwa apoptosis ya maselo a neuronal"
• Zimaletsa kupanga ma enzyme oyambitsa kutupa
• Kuletsa calcium kulowa m'maselo, motero kumalepheretsa:
◦ Kutulutsa ma cytokines oyambitsa kutupa
◦ Maselo a m'mimba amatulutsa histamine ndi serotonin 

Malinga ndi nkhaniyi, quercetin imathanso kulimbitsa maselo a mast, imakhala ndi ntchito yoteteza m'mimba, komanso "imakhudza mwachindunji magwiridwe antchito a maselo oteteza thupi", kotero kuti imatha "kuchepetsa kapena kuletsa njira zosiyanasiyana zotupa ndi ntchito," ndikuletsa kuchuluka kwa mamolekyulu omwe ali mu micromolar concentration range".

Quercetin ikhoza kukhala yowonjezera yothandiza kwa anthu ambiri

Poganizira ubwino wosiyanasiyana wa quercetin, ikhoza kukhala yowonjezera yothandiza kwa anthu ambiri, kaya ndi mavuto aakulu kapena a nthawi yayitali, ikhoza kukhala ndi zotsatirapo zinazake. Ichi ndi chowonjezera chomwe ndikukulimbikitsani kuti musunge mu kabati ya mankhwala. Chingakuthandizeni kwambiri mukamaganiza kuti "mukuvutika kwambiri" ndi vuto la thanzi (kaya ndi chimfine kapena chimfine).

Ngati mumakhala ndi chimfine ndi fuluwenza, mungaganizire kumwa quercetin miyezi ingapo chimfine ndi fuluwenza chisanafike kuti mulimbitse chitetezo chamthupi chanu. M'kupita kwa nthawi, zikuwoneka kuti ndizothandiza kwambiri kwa odwala omwe ali ndi vuto la metabolic syndrome, koma ndi kupusa kwambiri kudalira zowonjezera zina ndikulephera kuthetsa mavuto oyambira monga zakudya ndi masewera olimbitsa thupi nthawi imodzi.