1. Endothelin antagonists

Amachokera ku zitsamba zaku Europe za chamomile, zomwe zimatha kukana endothelin ndikuletsa kupanga ma melanocytes. Kugawidwa kosagwirizana kwa endothelin pakhungu ndiye chinthu chachikulu chomwe chimatsogolera kupanga mtundu wa pigmentation. Otsutsa a endothelin amatha kuletsa endothelin.. tyrosinase ndikulimbikitsa kusiyanitsa kwa melanocytes.

Kafukufuku wapeza kuti endothelin antagonists otengedwa kuchokera ku zamoyo zam'madzi ali ndi cytotoxicity yochepa ndipo amatha kulepheretsa kusiyanitsa kwa endothelin pa melanocytes ndi ntchito ya tyrosinase. Khungu hyperpigmentation matenda chifukwa cha kuchuluka - l akhoza ntchito chiyembekezo.

2. Resveratrol ndi zotumphukira zake

Resveratrolmakamaka lilipo mphesa, Polygonum cuspidatum, Veratrum ndi zomera zina, ndipo linalake ndipo tikulephera ntchito ya melanocytes ndi ntchito ya tyrosinase m'njira ndende amadalira, potero kuchepetsa kaphatikizidwe melanin. Jeong et al adapeza kuti imalumikizidwanso ndi mapuloteni okhudzana ndi tyrosinase mu melanogenesis.

Jia Lili ndi maphunziro ena awonetsa kuti topical resveratrol imatha kusintha bwino khungu, imakhala ndi kuyera kwina, ndipo ilibe zoyipa. Resveratrol ili ndi kuipa kwa kusakhazikika komanso kusapezeka kwa bioavailability. Kafukufuku wapeza kuti zotumphukira zake (pentaalkyl ether derivatives ndi tetraester derivatives) zimakhala ndi bioavailability yayikulu ndipo zimatha kuletsa bwino kaphatikizidwe ka melanin. Iwo ali ndi chiyembekezo ntchito yotakata mu whitening zodzoladzola.

3. Camellia Tingafinye

Camellia ndi banja la Camellia. Nakamura et al. anapeza kuti maluwa a camellia amatha kulepheretsa kupanga melanin ndikulimbikitsa kusiyana kwa fibroblast. Huang Xiaofeng ndi maphunziro ena atsimikiza kuti nthambi ya tiyi ya Dianshan ndi tsamba lamasamba ndilabwino kuposa arbutin potengera kuchuluka kwa maselo komanso kuletsa ntchito ya tyrosinase, ndipo ili ndi katundu wabwino kuposa arbutin. Ndi mtundu watsopano wa khungu woyera wothandizira ndipo ali osiyanasiyana ntchito. chiyembekezo.

MelaninSynthaseIcholetsa

1. Arbutin

Ndikofunikira kwa tyrosinase inhibitor, yomwe imatha kuletsa ntchito ya tyrosinase, kutsekereza kaphatikizidwe ka dopa ndi dopaquinone, potero kulepheretsa kupanga melanin, komanso kumachepetsa kwambiri ma pigmentation omwe amayamba chifukwa cha kuwala kwa ultraviolet, koma ndi okhazikika. photosensitivity.

Kafukufukuyu adapeza kuti arbutin yokhala ndi 3% imakhala ndi zinthu zabwino, cytotoxicity yochepa, kuyabwa ndi ziwengo, ndipo malire ake apamwamba sangadutse 7%. Kuchuluka kwa arbutin kumapangitsa khungu kukhala labwinobwino. Zomwe zimagwiritsidwa ntchito mwachilengedwe, glucopyranoside, zimakhala ndi mphamvu yolepheretsa anthu tyrosinase kuposa arbutin, ndipo imalowa m'malo mwa arbutin chifukwa imakhala yogwira mtima komanso yokhazikika.

2. Licorice Tingafinye

Zomwe zimagwira ntchito ndi liquiritin, isoliquiritin ndi licorice flavonoids. Liquiritin imapangitsa khungu la melanin kugawidwa mofanana ndi kufalitsa melanin yophatikizana, ndikukwaniritsa kuyera; ntchito yaikulu ya licorice flavonoids ndi kuletsa ntchito ya tyrosinase, DHICA oxidase ndi dopa pigment intermutase.

Kafukufuku wapeza kuti mankhwala osamalira khungu omwe ali ndi licorice ndi papain amatha kuthandiza melasma ndi post-inflammatory hyperpigmentation, ndi zotsatira zochepa, komanso kukhala ndi ... ndi ... Kuphatikizika kwake muzinthu zoyera ndi 10% mpaka 40%, koma zomwe zili mu licorice sizokwera ndipo kuyeretsa kumakhala kovuta komanso kokwera mtengo.

3. Chuanxiong Tingafinye

Kafukufuku wapeza kuti Chuanxiong Tingafinye amatha kuletsa bwino ntchito ya tyrosinase, kusonyeza mpikisano zoletsa zotsatira. Mafuta a Chuanqiong opangidwa ndi ma emulsifiers osiyanasiyana ndi zokometsera zosiyanasiyana, kafukufuku wokhudzana ndi kuyera kwake ndi magwiridwe antchito adawonetsa kuti 0.5% ~ 1.0% mafuta a Chuanqiong ali ndi kukhazikika kwabwino, magwiridwe antchito apamwamba komanso kuyera bwino.

4. Rhodiola rosea Extract

Salidroside ndi flavonoids ndi zigawo zake zazikulu zogwira ntchito, ndipo salidroside imatha kuwononga lipids ndi nembanemba zama cell ndi cheza cha ultraviolet. Tingafinye akhoza ziletsa synthesis wa melanin ndi ntchito ya tyrosinase, ndipo ndi ogwira whitening akhungu wothandizira. Kafukufukuyu adapeza kuti 1% ndi 5% ya Rhodiola rosea Tingafinye sizinayambitse mavuto m'thupi la munthu, ndipo ndi zodzikongoletsera yogwira pophika ndi mkulu bata ndipo ali ndi chiyembekezo chotakata pa ntchito zodzikongoletsera.

5. Aloin

Ndi chomera chochepa cha molekyulu cha glycoprotein chotengedwa ku aloe vera. Imalepheretsa makamaka mapangidwe a dopaquinone mwa kuletsa mpikisano wa dopa oxidation site, ndipo imakwaniritsa zoletsa zopanda mpikisano mwa kuletsa mpikisano wamkuwa pa malo a hydroxylase. Ntchito ya tyrosine hydroxylase. Kuonjezera apo, aloin amathanso kuchepetsa khungu lakuda chifukwa cha kuwala kwa ultraviolet, ndipo amakhala ndi zotsatira zabwino zokonzanso khungu pambuyo pa dzuwa. Aloin ndi hydrophilic komanso si cytotoxic. Kusakaniza aloin ndi arbutin kumatha kusintha mawonekedwe a whitening.

6. Zomera za Polyphenols

Zimapezeka makamaka mu khungwa, mizu, masamba ndi zipatso za zomera, ndipo kuyera kwake kumakhudzana makamaka ndi kuyamwa kwake kwa cheza cha ultraviolet, kuchotsa antioxidant kwa free radicals, ndi kulepheretsa ntchito za tyrosinase ndi peroxidase. Ellagic acid ndi polyphenol yachilengedwe yotengedwa ku peel ya makangaza, makungwa ndi zipatso ndi ndiwo zamasamba zosiyanasiyana. Ikhoza kulepheretsa kuchuluka kwa melanocyte, kulepheretsa ntchito ya melanocyte tyrosinase, kuchepetsa kaphatikizidwe ka melanin, kuwala kwa ultraviolet kumakhala ndi mphamvu yoyamwa kwambiri, yomwe ingathandize kuteteza dzuwa kapena kuwononga ma radicals aulere mwa kuyamwa cheza cha ultraviolet. Chomera cha polyphenol ndi chinthu chothandiza kwambiri, chomwe chili ndi chiyembekezo chachikulu pakupanga ndikugwiritsa ntchito zodzoladzola.

Zambiri:
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Woyang'anira kunja: Jason
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