Mu kafukufuku watsopano, ofufuza adapeza kuti mankhwala atsopano ozikidwa pa chigawo cha njere ya mphesa amatha kukulitsa moyo wa mbewa komanso thanzi la mbewa.
Kafukufukuyu, wofalitsidwa mu nyuzipepala ya Nature Metabolism, akuyala maziko a maphunziro owonjezera azachipatala kuti adziwe ngati zotsatirazi zingatheke mwa anthu.
Kukalamba ndi chinthu chachikulu chomwe chimayambitsa matenda ambiri osatha. Asayansi amakhulupirira kuti izi zimachitika chifukwa cha kukalamba kwa ma cell. Izi zimachitika pamene maselo sangathenso kugwira ntchito zawo zamoyo m'thupi.
M'zaka zaposachedwa, ofufuza apeza gulu lamankhwala lotchedwa senolytics. Mankhwalawa amatha kuwononga ma cell a senescent mu labotale ndi zitsanzo za nyama, zomwe zingachepetse kuchuluka kwa matenda osatha omwe amabwera tikamakalamba ndikukhala ndi moyo wautali.
Mu kafukufukuyu, asayansi adapeza senolytic yatsopano yochokera ku chigawo cha njere ya mphesa yotchedwa proanthocyanidin C1 (PCC1).
Kutengera zomwe zidachitika m'mbuyomu, PCC1 ikuyembekezeka kuletsa ma cell a senescent m'malo otsika ndikuwononga ma cell a senescent pamalo okwera kwambiri.
Pakuyesa koyamba, adawonetsa mbewa pamilingo yocheperako ya radiation kuti apangitse ma cell senescence. Gulu limodzi la mbewa kenako linalandira PCC1, ndipo gulu lina linalandira galimoto yonyamula PCC1.
Ofufuzawa adapeza kuti mbewazo zitawonetsedwa ndi ma radiation, zidakhala ndi mawonekedwe osadziwika bwino, kuphatikiza imvi zambiri.
Kuchiza mbewa ndi PCC1 kunasintha kwambiri izi. Makoswe opatsidwa PCC1 analinso ndi ma cell a senescent ochepa komanso ma biomarker okhudzana ndi ma cell a senescent.
Potsirizira pake, mbewa zowonongeka zinali ndi ntchito zochepa komanso mphamvu za minofu. Komabe, zinthu zinasintha mu mbewa zopatsidwa PCC1, ndipo anali ndi moyo wapamwamba.
Pakuyesa kwachiwiri, ofufuzawo adabaya mbewa zokalamba ndi PCC1 kapena galimoto milungu iwiri iliyonse kwa miyezi inayi.
Gululo linapeza maselo ambiri a senescent mu impso, chiwindi, mapapo ndi prostates a mbewa zakale. Komabe, chithandizo cha PCC1 chinasintha zinthu.
Makoswe omwe amathandizidwa ndi PCC1 adawonetsanso kusintha kwa mphamvu zogwira, kuthamanga kwambiri, kuthamanga kwapang'onopang'ono, kupirira kwa treadmill, mlingo wa zochitika za tsiku ndi tsiku, komanso moyenera poyerekeza ndi mbewa zomwe zinalandira galimoto yokha.
Pakuyesa kwachitatu, ofufuzawo adayang'ana mbewa zakale kwambiri kuti awone momwe PCC1 idakhudzira moyo wawo.
Iwo adapeza kuti mbewa zomwe zimathandizidwa ndi PCC1 zimakhala ndi nthawi yayitali ya 9.4% kuposa mbewa zomwe zimagwiritsidwa ntchito ndi galimoto.
Komanso, ngakhale atakhala ndi moyo wautali, mbewa zothandizidwa ndi PCC1 sizinawonetse matenda okhudzana ndi ukalamba poyerekeza ndi mbewa zothandizidwa ndi galimoto.
Pofotokoza mwachidule zomwe apeza, wolemba mabuku wina, Pulofesa Sun Yu wa ku Shanghai Institute of Nutrition and Health ku China ndi anzake anati: “Pamenepa tikupereka umboni wakuti [PCC1] imatha kuchedwetsa kwambiri vuto la ukalamba ngakhale litatengedwa.” m’moyo, ali ndi kuthekera kwakukulu kochepetsera matenda obwera chifukwa cha ukalamba ndi kuwongolera zotulukapo za thanzi, motero amatsegula njira zatsopano zamankhwala ochiritsira amtsogolo kuti akhale ndi thanzi labwino ndi moyo wautali.”
Dr James Brown, membala wa Aston Center for Healthy Aging ku Birmingham, UK, adauza Medical News Today kuti zomwe zapezazi zimapereka umboni wina wa ubwino wa mankhwala oletsa kukalamba. Dr. Brown sanachite nawo kafukufuku waposachedwapa.
"Senolytics ndi gulu latsopano la mankhwala oletsa kukalamba omwe amapezeka mwachilengedwe. Kafukufukuyu akuwonetsa kuti PCC1, pamodzi ndi mankhwala monga quercetin ndi fisetin, amatha kupha ma cell a senescent pomwe amalola maselo achichepere, athanzi kukhalabe olimba. ”
"Kafukufukuyu, monganso maphunziro ena a m'derali, adawunikira zotsatira za mankhwalawa mu makoswe ndi zamoyo zina zotsika, kotero kuti patsala ntchito yambiri kuti zotsatira zotsutsa kukalamba za mankhwalawa mwa anthu zidziwike."
"Senolytics ndithudi ali ndi lonjezo lokhala mankhwala oletsa kukalamba pa chitukuko," adatero Dr. Brown.
Pulofesa Ilaria Bellantuono, pulofesa wa ukalamba wa musculoskeletal ku yunivesite ya Sheffield ku UK, adavomereza poyankhulana ndi MNT kuti funso lofunika kwambiri ndiloti zomwe zapezazi zikhoza kufotokozedwa mwa anthu. Pulofesa Bellantuono nayenso sanachite nawo phunziroli.
"Kafukufukuyu akuwonjezera umboni wosonyeza kuti kuloza maselo am'mimba ndi mankhwala omwe amawapha, otchedwa 'senolytics,' amatha kusintha magwiridwe antchito a thupi tikamakalamba ndikupanga mankhwala a chemotherapy kukhala othandiza kwambiri pa khansa."
"Ndikofunikira kudziwa kuti zonse zomwe zili m'derali zimachokera ku zinyama - pamenepa, zitsanzo za mbewa. Vuto lenileni ndilo kuyesa ngati mankhwalawa ali othandiza mofanana [mwa anthu]. Palibe deta yomwe ilipo pakadali pano. ” , ndipo mayesero azachipatala angoyamba kumene,” anatero Pulofesa Bellantuono.
Dr David Clancy, wa Faculty of Biomedicine and Biological Sciences ku Lancaster University ku UK, adauza MNT kuti kuchuluka kwa mlingo kumatha kukhala vuto mukamagwiritsa ntchito zotsatira kwa anthu. Dr. Clancy sanachite nawo kafukufuku waposachedwapa.
Mlingo woperekedwa kwa mbewa nthawi zambiri umakhala waukulu kwambiri poyerekeza ndi zomwe anthu amatha kulekerera. Mlingo woyenera wa PCC1 mwa anthu ungayambitse kawopsedwe. Maphunziro a makoswe angakhale odziwitsa; chiwindi chawo chimaoneka kuti chimatulutsa mankhwala monga chiwindi cha munthu kuposa chiwindi cha mbewa. ”
Dr Richard Siow, mkulu wa kafukufuku wokalamba ku King's College London, adauzanso MNT kuti kafukufuku wa nyama zomwe si za anthu sizingabweretse zotsatira zabwino zachipatala mwa anthu. Dr. Siow nayenso sanachite nawo kafukufukuyu.
“Nthawi zonse sindimayerekeza kupezeka kwa makoswe, nyongolotsi ndi ntchentche, chifukwa chosavuta ndichakuti tili ndi maakaunti aku banki ndipo alibe. Tili ndi zikwama, koma alibe. Tili ndi zinthu zina m’moyo. Tsindikani kuti nyama Tilibe: chakudya, kulankhulana, ntchito, Zoom mafoni. Ndikukhulupirira kuti makoswe amatha kupanikizika m'njira zosiyanasiyana, koma nthawi zambiri timakhudzidwa kwambiri ndi ndalama zathu za banki, "adatero Dr. Xiao.
"Zowonadi, izi ndi nthabwala, koma pazonse zomwe mumawerenga za mbewa sizingamasuliridwe kwa anthu. Mukadakhala mbewa ndipo mukufuna kukhala zaka 200 - kapena zofanana ndi mbewa. Pazaka 200, izi zingakhale zabwino, koma kodi ndizomveka kwa anthu? Nthawi zonse ndimachenjeza ndikakamba za kafukufuku wa nyama. ”
"Kumbali yabwino, iyi ndi phunziro lamphamvu lomwe limatipatsa umboni wamphamvu wakuti ngakhale njira zambiri zomwe ndikuyang'ana pa kafukufuku wanga ndizofunikira tikaganizira za moyo wonse."
"Kaya ndi chitsanzo cha nyama kapena chitsanzo chaumunthu, pangakhale njira zina zamagulu zomwe tiyenera kuziyang'ana pazochitika za mayesero a zachipatala a anthu omwe ali ndi mankhwala monga mphesa proanthocyanidins," adatero Dr. Siow.
Dr. Xiao adati chotheka chimodzi ndikupanga mbewu za mphesa monga chowonjezera chazakudya.
“Kukhala ndi chitsanzo chabwino cha nyama chokhala ndi zotulukapo zabwino [ndi kufalitsidwa m’magazini okhudza chikoka chachikulu] kumawonjezera chiwongolero ku chitukuko ndi ndalama zofufuza zachipatala za anthu, kaya kuchokera ku boma, mayesero a zachipatala kapena kudzera mwa osunga ndalama ndi makampani. Tengani gulu lazovutali ndikuyika mbewu zamphesa m'mapiritsi ngati chowonjezera pazakudya potengera nkhanizi. ”
"Zowonjezera zomwe ndikutenga mwina sizinayesedwe, koma deta ya nyama imasonyeza kuti imawonjezera kulemera - zomwe zimapangitsa ogula kukhulupirira kuti pali chinachake mmenemo. Ndi mbali ya mmene anthu amaganizira za chakudya.” zowonjezera." mwanjira zina, izi ndizothandiza kumvetsetsa moyo wautali, "adatero Dr. Xiao.
Dr. Xiao anatsindika kuti moyo wa munthu ndi wofunikanso, osati nthawi yomwe amakhala.
“Ngati timasamala za kutalika kwa moyo komanso, koposa zonse, kutalika kwa moyo, tifunika kufotokoza tanthauzo la kukhala ndi moyo. Sizingakhale bwino ngati tikhala zaka 150, koma sizili bwino ngati tikhala zaka 50 zapitazi pabedi. ”
"Chotero m'malo mokhala ndi moyo wautali, mwina nthawi yabwinoko ingakhale thanzi ndi moyo wautali: mungakhale mukuwonjezera zaka ku moyo wanu, koma kodi mukuwonjezera zaka ku moyo wanu? Kapena zaka zimenezi zilibe tanthauzo? Ndipo thanzi labwino m'maganizo: mutha kukhala ndi moyo zaka 130. wakalamba, koma ngati simungathe kusangalala nazo zaka zimenezi, kodi n’koyenera?”
"Ndikofunikira kuti tiyang'ane momwe malingaliro athu onse amakhudzira thanzi labwino, kufooka, kusayenda bwino, momwe timakalamba pagulu - pali mankhwala okwanira? Kapena timafunikira chisamaliro chochulukirapo? Ngati tili ndi chithandizo chokhala ndi moyo ku 90, 100 kapena 110? Kodi boma lili ndi ndondomeko?"
“Ngati mankhwalawa akutithandiza, ndipo takwanitsa zaka 100, tingatani kuti tikhale ndi moyo wabwino m’malo mongomwa mankhwala ambiri? Pano muli ndi mbewu zamphesa, makangaza, ndi zina zotero,” anatero Dr. Xiao. .
Pulofesa Bellantuono adati zotsatira za kafukufukuyu zingakhale zofunikira kwambiri pamayesero azachipatala okhudza odwala khansa omwe amalandira mankhwala a chemotherapy.
"Vuto lomwe limakhalapo ndi ma senolytics ndikudziwitsa omwe angapindule nawo komanso momwe angayesere kupindula pamayesero azachipatala."
"Kuphatikiza apo, chifukwa mankhwala ambiri ndi othandiza kwambiri popewa matenda m'malo mochiza atapezeka, kuyesa kwachipatala kungatenge zaka zambiri malinga ndi momwe zinthu zilili ndipo zingakhale zodula kwambiri."
"Komabe, pankhaniyi, [ofufuzawo] adapeza gulu la odwala omwe angapindule nawo: odwala khansa omwe amalandila chithandizo chamankhwala. Komanso, zimadziwika pamene mapangidwe a maselo a senescent amapangitsidwa (ie ndi mankhwala amphamvu) komanso pamene "Ichi ndi chitsanzo chabwino cha kafukufuku wotsimikiziranso zomwe zingatheke kuyesa mphamvu za senolytics mwa odwala," adatero Pulofesa. Bellantuono. ”
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