Mu kafukufuku watsopano, ofufuza adapeza kuti mankhwala atsopano opangidwa kuchokera ku gawo la mbewu ya mphesa amatha kukulitsa moyo wa mbewa komanso thanzi lawo.
Kafukufukuyu, wofalitsidwa mu magazini ya Nature Metabolism, akukhazikitsa maziko a maphunziro ena azachipatala kuti adziwe ngati zotsatirazi zingathe kubwerezedwanso mwa anthu.
Ukalamba ndi chinthu chachikulu chomwe chimayambitsa matenda ambiri osatha. Asayansi amakhulupirira kuti izi zimachitika chifukwa cha ukalamba wa maselo. Izi zimachitika pamene maselo sangathenso kuchita ntchito zawo zamoyo m'thupi.
M'zaka zaposachedwapa, ofufuza apeza mtundu wa mankhwala otchedwa senolytics. Mankhwalawa amatha kuwononga maselo okalamba m'ma laboratories ndi zinyama, zomwe zingachepetse kuchuluka kwa matenda osatha omwe amayamba tikamakalamba ndikukhala ndi moyo wautali.
Mu kafukufukuyu, asayansi adapeza njira yatsopano yodziwira matenda yomwe imachokera ku gawo la mbewu ya mphesa yotchedwa proanthocyanidin C1 (PCC1).
Kutengera ndi deta yam'mbuyomu, PCC1 ikuyembekezeka kuletsa ntchito ya maselo okalamba pamlingo wotsika ndikuwononga maselo okalamba pamlingo wapamwamba.
Mu kuyesa koyamba, adawonetsa mbewa ku mphamvu ya kuwala kochepa kuti ziwongolere kukula kwa maselo. Gulu limodzi la mbewa kenako linalandira PCC1, ndipo gulu linalo linalandira galimoto yonyamula PCC1.
Ofufuzawo adapeza kuti mbewa zitayamba kukhudzidwa ndi kuwala kwa dzuwa, zinayamba kukhala ndi mawonekedwe osazolowereka, kuphatikizapo tsitsi lalikulu la imvi.
Kuchiza mbewa ndi PCC1 kunasintha kwambiri makhalidwe amenewa. Mbewa zomwe zinapatsidwa PCC1 zinalinso ndi maselo ochepa a senescent ndi zizindikiro zodziwika bwino zokhudzana ndi maselo a senescent.
Pomaliza, mbewa zomwe zinayatsidwa ndi kuwala kwa dzuwa zinali ndi mphamvu zochepa komanso minofu inali yofooka. Komabe, zinthu zinasintha m'mbewa zomwe zinapatsidwa PCC1, ndipo zinali ndi moyo wautali.
Mu kafukufuku wachiwiri, ofufuzawo adabaya mbewa zokalamba ndi PCC1 kapena galimoto milungu iwiri iliyonse kwa miyezi inayi.
Gululi linapeza maselo ambiri okhwima m'impso, chiwindi, mapapo ndi prostate ya mbewa zakale. Komabe, chithandizo cha PCC1 chinasintha zinthu.
Mbewa zomwe zinalandira chithandizo cha PCC1 zinawonetsanso kusintha kwa mphamvu yogwirira, liwiro lalikulu loyenda, kupirira kopachikika, kupirira kwa makina oyezera, kuchuluka kwa zochita za tsiku ndi tsiku, komanso kulinganiza bwino poyerekeza ndi mbewa zomwe zinalandira galimoto yokha.
Mu kafukufuku wachitatu, ofufuzawo adayang'ana mbewa zakale kwambiri kuti aone momwe PCC1 idakhudzira moyo wawo.
Iwo adapeza kuti mbewa zomwe zalandira chithandizo cha PCC1 zimakhala ndi moyo wautali ndi 9.4% kuposa mbewa zomwe zalandira chithandizo cha galimoto.
Komanso, ngakhale kuti anakhala ndi moyo nthawi yayitali, mbewa zomwe zinalandira chithandizo cha PCC1 sizinawonetse matenda aakulu okhudzana ndi ukalamba poyerekeza ndi mbewa zomwe zinalandira chithandizo cha galimoto.
Pofotokoza mwachidule zomwe zapezeka, wolemba nkhani Sun Yu wochokera ku Shanghai Institute of Nutrition and Health ku China ndi anzake anati: “Panopa tikupereka umboni wakuti [PCC1] imatha kuchedwetsa kwambiri matenda okhudzana ndi ukalamba ngakhale itagwiritsidwa ntchito mtsogolo.” Mankhwalawa ali ndi kuthekera kwakukulu kochepetsa matenda okhudzana ndi ukalamba ndikukweza zotsatira zaumoyo, potero kutsegula njira zatsopano zamankhwala okalamba amtsogolo kuti akonze thanzi ndi moyo wautali.”
Dokotala James Brown, membala wa Aston Center for Healthy Aging ku Birmingham, UK, adauza Medical News Today kuti zomwe zapezekazi zikupereka umboni wina wa ubwino womwe ungakhalepo wa mankhwala oletsa ukalamba. Dokotala Brown sanachite nawo kafukufuku waposachedwapa.
"Ma senolytics ndi gulu latsopano la mankhwala oletsa ukalamba omwe amapezeka kwambiri m'chilengedwe. Kafukufukuyu akuwonetsa kuti PCC1, pamodzi ndi mankhwala monga quercetin ndi fisetin, amatha kupha maselo okalamba mwachisawawa pomwe amalola maselo achichepere, athanzi kuti akhalebe ndi moyo wabwino."
"Kafukufukuyu, monga maphunziro ena m'derali, adafufuza momwe mankhwala awa amakhudzira makoswe ndi zamoyo zina zotsika, kotero ntchito yambiri yatsala isanadziwike kuti mankhwala awa amakhudza bwanji ukalamba mwa anthu."
"Madokotala a senolytics ali ndi lonjezo lokhala mankhwala otsogolera oletsa ukalamba omwe akukula," adatero Dr. Brown.
Pulofesa Ilaria Bellantuono, pulofesa wa ukalamba wa minofu ndi mafupa ku Yunivesite ya Sheffield ku UK, adavomereza poyankhulana ndi MNT kuti funso lofunika kwambiri ndilakuti kodi zomwe zapezekazi zitha kubwerezedwanso mwa anthu. Pulofesa Bellantuono nayenso sanachite nawo kafukufukuyu.
"Kafukufukuyu akuwonjezera umboni woti kugwiritsa ntchito mankhwala opha maselo okalamba, otchedwa 'senolytics,' kungathandize kuti thupi lizigwira ntchito bwino pamene tikukalamba komanso kuti mankhwala a chemotherapy azigwira ntchito bwino kwambiri pa khansa."
"Ndikofunikira kudziwa kuti deta yonse yomwe ili m'derali imachokera ku zitsanzo za nyama—pankhaniyi, zitsanzo za mbewa. Vuto lenileni ndi kuyesa ngati mankhwala awa ndi othandiza mofanana [mwa anthu]. Palibe deta yomwe ilipo pakadali pano." , ndipo mayeso azachipatala akuyamba kumene," adatero Pulofesa Bellantuono.
Dr. David Clancy, wochokera ku Faculty of Biomedicine and Biological Sciences ku Lancaster University ku UK, adauza MNT kuti kuchuluka kwa mlingo kungakhale vuto poika zotsatira zake kwa anthu. Dr. Clancy sanachite nawo kafukufuku waposachedwa.
"Milingo yomwe imaperekedwa kwa mbewa nthawi zambiri imakhala yayikulu kwambiri poyerekeza ndi yomwe anthu amatha kupirira. Mlingo woyenera wa PCC1 mwa anthu ungayambitse poizoni. Kafukufuku mwa makoswe akhoza kukhala wothandiza; chiwindi chawo chikuwoneka kuti chimasintha mankhwala ngati chiwindi cha munthu kuposa chiwindi cha mbewa."
Dr. Richard Siow, mkulu wa kafukufuku wa ukalamba ku King's College London, adauzanso MNT kuti kafukufuku wosakhala wa anthu pa nyama sangabweretse zotsatira zabwino zachipatala mwa anthu. Dr. Siow nayenso sanachite nawo kafukufukuyu.
"Sindimakonda kuyerekezera kupezeka kwa makoswe, nyongolotsi ndi ntchentche ndi anthu, chifukwa chosavuta ndichakuti tili ndi maakaunti akubanki ndipo alibe. Tili ndi ma wallet, koma alibe. Tili ndi zinthu zina m'moyo. Tsindikani kuti nyama zomwe tilibe: chakudya, kulumikizana, ntchito, kuyimba kwa Zoom. Ndikutsimikiza kuti makoswe amatha kukhala ndi nkhawa m'njira zosiyanasiyana, koma nthawi zambiri timada nkhawa kwambiri ndi ndalama zomwe tili nazo kubanki," adatero Dr. Xiao.
"Zachidziwikire, izi ndi nthabwala, koma pankhani yake, chilichonse chomwe mumawerenga chokhudza mbewa sichingamasuliridwe kwa anthu. Ngati mukanakhala mbewa ndipo mukufuna kukhala ndi moyo wa zaka 200 - kapena zofanana ndi mbewa. Pazaka 200, zimenezo zikanakhala zabwino, koma kodi zimakhala zomveka kwa anthu? Nthawi zonse ndimakhala chenjezo ndikalankhula za kafukufuku wa nyama."
"Kumbali yabwino, uwu ndi kafukufuku wamphamvu womwe umatipatsa umboni wamphamvu wakuti ngakhale njira zambiri zomwe kafukufuku wanga adayang'ana ndizofunikira tikamaganizira za moyo wonse."
"Kaya ndi chitsanzo cha nyama kapena chitsanzo cha munthu, pakhoza kukhala njira zinazake zomwe tifunika kuziyang'ana potengera mayeso azachipatala a anthu ndi mankhwala monga proanthocyanidins ya mbewu za mphesa," adatero Dr. Siow.
Dokotala Xiao anati njira imodzi yomwe ingatheke ndi kupanga chotsitsa cha mbewu za mphesa ngati chowonjezera pazakudya.
"Kukhala ndi chitsanzo chabwino cha nyama chokhala ndi zotsatira zabwino [ndi kusindikizidwa mu magazini yokhudza kwambiri] kumawonjezera kulemera kwa chitukuko ndi ndalama zomwe zimagwiritsidwa ntchito mu kafukufuku wa zachipatala wa anthu, kaya kuchokera ku boma, mayesero azachipatala kapena kudzera mwa osunga ndalama ndi mafakitale. Tengani bolodi loyesera ili ndikuyika mbewu za mphesa m'mapiritsi ngati chowonjezera pazakudya kutengera nkhani izi."
"Chowonjezera chomwe ndikumwa mwina sichinayesedwe kuchipatala, koma deta ya nyama ikusonyeza kuti chimawonjezera kulemera - zomwe zimapangitsa ogula kukhulupirira kuti pali china chake mkati mwake. Ndi gawo la momwe anthu amaganizira za chakudya." zowonjezera." mwanjira zina, izi ndizothandiza kumvetsetsa moyo wautali," adatero Dr. Xiao.
Dokotala Xiao anagogomezera kuti moyo wa munthu ndi wofunika kwambiri, osati nthawi yokha yomwe amakhala.
"Ngati tikusamala za nthawi yomwe munthu amayembekezera kukhala ndi moyo, komanso chofunika kwambiri, nthawi yomwe munthu amayembekezera kukhala ndi moyo, tiyenera kudziwa tanthauzo la nthawi yomwe munthu amayembekezera kukhala ndi moyo. Palibe vuto ngati titakhala ndi moyo zaka 150, koma sizosangalatsa ngati titakhala zaka 50 zapitazi tili pabedi."
"Choncho m'malo mwa kukhala ndi moyo wautali, mwina nthawi yabwino ingakhale thanzi ndi moyo wautali: mwina mukuwonjezera zaka pa moyo wanu, koma kodi mukuwonjezera zaka pa moyo wanu? Kapena kodi zaka zimenezi zilibe tanthauzo? Ndipo thanzi la maganizo: mutha kukhala ndi moyo wa zaka 130, koma ngati simungathe kusangalala ndi zaka zimenezi, kodi ndizoyenera?"
"Ndikofunikira kuti tiyang'ane bwino za thanzi la maganizo ndi ubwino, kufooka, mavuto oyenda, momwe timakalamba m'dera lathu - kodi pali mankhwala okwanira? Kapena kodi tikufunika chisamaliro cha anthu ambiri? Ngati tili ndi chithandizo kuti tikhale ndi moyo wa zaka 90, 100 kapena 110? Kodi boma lili ndi mfundo?"
"Ngati mankhwala awa akutithandiza, ndipo tili ndi zaka zoposa 100, kodi tingatani kuti tiwongolere moyo wathu m'malo mongomwa mankhwala ena? Pano muli ndi mbewu za mphesa, makangaza, ndi zina zotero," anatero Dr. Xiao.
Pulofesa Bellantuono anati zotsatira za kafukufukuyu zidzakhala zothandiza kwambiri pa mayeso azachipatala okhudza odwala khansa omwe akulandira chithandizo cha chemotherapy.
"Vuto lofala ndi mankhwala a senolytic ndikudziwa omwe angapindule nawo komanso momwe angayesere phindu m'mayesero azachipatala."
"Kuphatikiza apo, chifukwa mankhwala ambiri ndi othandiza kwambiri popewa matenda m'malo mochiza akapezeka, mayeso azachipatala angatenge zaka zambiri kutengera momwe zinthu zilili ndipo angakhale okwera mtengo kwambiri."
"Komabe, pankhaniyi, [ofufuza] adapeza gulu la odwala omwe angapindule ndi izi: odwala khansa omwe amalandira chemotherapy. Kuphatikiza apo, zimadziwika nthawi yomwe kupangika kwa maselo obadwa kumene kumayambitsidwa (monga chemotherapy) ndi nthawi yomwe "Ichi ndi chitsanzo chabwino cha kafukufuku wotsimikizira lingaliro lomwe lingachitike kuti ayesere kugwira ntchito kwa senolytics mwa odwala," adatero Pulofesa Bellantuono.
Asayansi apambana komanso mosamala kuthetsa zizindikiro za ukalamba mwa mbewa mwa kusintha majini a maselo awo.
Kafukufuku wa ku Baylor College of Medicine adapeza kuti zowonjezera zimachedwetsa kapena kukonza mbali za ukalamba wachilengedwe mwa mbewa, zomwe zitha kutalikitsa nthawi…
Kafukufuku watsopano wa mbewa ndi maselo a anthu wapeza kuti mankhwala a zipatso amatha kuchepetsa kuthamanga kwa magazi. Kafukufukuyu akuwonetsanso njira yokwaniritsira cholinga ichi.
Asayansi anathira magazi a mbewa zakale m'makoswe aang'ono kuti aone momwe zimakhudzira ndi kuona ngati komanso momwe angachepetsere zotsatira zake.
Zakudya zoletsa ukalamba zikutchuka kwambiri. Munkhaniyi tikambirana zomwe zapezeka mu ndemanga yaposachedwa ya umboni ndikufunsa ngati pali chilichonse mwa izi…