Kuyamba kwa Citrus Aurantium

Citrus Aurantium, chomera cha banja la rutaceae, chimafalitsidwa kwambiri ku China. Citrus aurantium ndi dzina lachi China la laimu. M'mankhwala achi China, citrus aurantium ndi therere lachikhalidwe lomwe limagwiritsidwa ntchito kukulitsa chidwi komanso kuwongolera qi (mphamvu). Ku Italy, citrus aurantium yakhalanso mankhwala azikhalidwe azikhalidwe kuyambira zaka za zana la 16, omwe amagwiritsidwa ntchito pochiza malungo monga malungo komanso ngati antimicrobial. Kafukufuku waposachedwapa wasonyeza kuti citrus aurantium akhoza m'malo ephedra pa matenda a kunenepa popanda chokhwima mtima mavuto.

Zothandiza za citrus aurantium ndi hesperidin, neohesperidin, nobiletin, auranetin, aurantiamarin, nuringin, synephrine, limonin.

Yogwira pophika

Hesperidin, neohesperidin, nobiletin, D-limonene, auranetin, aurantiamarin, citrin, synephrine, limonin.

Katundu wakuthupi

Crystallization, kusungunuka mfundo 184-1850C, carbonate crystallization 151-152, mosavuta sungunuka m'madzi. Bitartrate, melting point 188-189, sungunuka m'madzi, zovuta kusungunuka mu Mowa, pafupifupi osasungunuka mu chloroform, ether. Hydrochloride, kristalo wopanda mtundu (ethanol-ethyl ether), malo osungunuka 166-167. Racemization ndiyosavuta kuchitika pakulekanitsa kwa chromatography ya asidi amphamvu ndi utomoni wosinthira ma ion.

Pharmacological zotsatira
1. Zotsatira pa chiberekero: Fructus Aurantii ndi Fructus Aurantii Fructus Decoction kuchokera kumadera atatu opangira (Sichuan, Jiangxi, ndi Hunan) adawonetsa zotsatira zolepheretsa chiberekero mu vitro ya mbewa (oyembekezera ndi omwe alibe mimba); Chiberekero cha kalulu chinali chokondwa mu vivo ndi m'mimba (woyembekezera komanso wosayembekezera). Fistula ya chiberekero ya Kalulu inatsimikiziranso kuti imapangitsa kuti chiberekero cha chiberekero chikhale cholimba, chiwonjezeko chowonjezereka, komanso ngakhale kutsika kwa tetanic. Tincture ya Fructus Aurantii ndi Fructus Aurantii fluid imathanso kusangalatsa chiberekero cha kalulu (mu vivo ndi mu vitro). Chiberekero cha mbewa (in vitro) chinali choletsedwa. Katundu wina wa alkaloid wolekanitsidwa ndi Fructus Aurantii ndi Lycium orange analinso ndi vuto linalake pa chiberekero cha kalulu mu vitro, makamaka pa minofu ya chiberekero yokondwa ndi pituitrin. Mbali ya alkaloid yochotsedwa inali ndi mpumulo pa chiberekero cha kalulu mu vitro, ndipo kumasuka kwa chiberekero kunali koonekeratu pambuyo pa chisangalalo cha hypophysial. Cirantin, wosiyana ndi Fructus Aurantii Fructus Peel, amalepheretsa ntchito ya hyaluronate kuzungulira ovary, yomwe ingakhale yokhudzana ndi kulera kwake (kuletsa umuna).

2. Mmene matumbo: Fructus Aurantii ndi Fructus Aurantii ochokera kumadera atatu osiyanasiyana amalepheretsa matumbo a mbewa ndi akalulu; Machubu ambiri a m'mimba mwa akalulu anali oletsedwa, koma ochepa analibe kusintha. Fructus Aurantii ndi madzi ake amadzimadzi amalepheretsa matumbo a mbewa (in vitro) ndi akalulu (in vitro). Kuphatikizika kwakukulu (1: 1000) kunalepheretsa matumbo ang'onoang'ono a akalulu akutali ndi nkhumba za nkhumba ndikuletsa zotsatira za acetylcholine ndi histamine. Kukhazikika kochepa (1: 10 000), patatha nthawi yochepa yolepheretsa, ikhoza kusonyeza chisangalalo, matalikidwe akuwonjezeka, ndi kuwonjezereka kwafupipafupi. Mu agalu anesthetized, kukhalapo kwa matumbo kunaletsedwa mwachiwonekere ndi decoctions. Koma kwa agalu omwe ali ndi gastroenterostomy, ali ndi mphamvu yosangalatsa, yomwe ingapangitse kuyenda kwa m'mimba ndi kutsekemera kwamphamvu.

3. Zotsatirapo pa mtima ndi mitsempha ya magazi: kukondwa pang'ono ndi kulepheretsa kwakukulu pamtima wa chule mu vitro. Fructus Aurantii ndi Fructus Aurantii Aurantii aqueous decoction, Fructus Aurantii tincture, ndi kuchotsa madzimadzi ndizofanana. Fructus Aurantii decoction kapena mowa wothira jekeseni kudzera m'mitsempha ukhoza kupititsa patsogolo kukakamiza kwambiri. Fructus Aurantii ndi Fructus Aurantii Fructus ochokera kumadera atatu osiyanasiyana adatsimikiziridwa kuti ali ndi zotsatira zochepa za vasoconstriction ndi kutsekemera kwa thupi lonse la achule. Mu agalu anesthetized, panali kwambiri ndi mofulumira hypertensive zotsatira. Panalibe kuvutika kupuma kapena hypotension chifukwa cha epinephrine, ndipo panalibe kuwonjezeka koonekeratu kwa kugunda kwa mtima.

Njira yolimbikitsira mphamvu imagwirizana ndi zinthu izi:

3.1. Kukomera kwa α zolandilira, zomwe zimayambitsa vasoconstriction m'ziwalo zina (phenylzoline imatha kusinthira kupsinjika kwamphamvu kwa antihypertensive reaction).

3.2. Kuchulukitsa kwa myocardial contraction ndikuwonjezera kutulutsa kwa mtima (kupatula kutulutsa kwamtima kwa nkhumba ndi kukonzekera kwa mtima). Pambuyo pa reserpine, mphamvu yowonjezera mphamvu ya Fructus aurantii aurantii inali yofunika kwambiri. Zinawonjezera kwambiri kuthamanga kwa mitsempha ya m'mitsempha (289.4% yowonjezera mitsempha ya mtsempha wamagazi ndi kuwira flowmeter) ndikuwonjezeka kwa ubongo ndi magazi a impso ndi 86.4% ndi 64.5% pafupifupi, zomwe zinali zosiyana kwambiri ndi norepinephrine. Panali kuchepa kwa magazi a chikazi komanso kuwonjezeka pang'ono koma kochepa kwa mpweya wa myocardial, zomwe sizinagwirizane ndi kuwonjezeka kwakukulu kwa mitsempha ya mitsempha. Mu ECG mayesero agalu ndi Guinea nkhumba, arrhythmia (mitsempha yamagazi tachycardia kapena atrioventricular chipika) chifukwa chachikulu mlingo wa aurantii aurantii sanali kwambiri. Kutengera ndi zomwe tafotokozazi, akuti kuchitira cardiogenic shock. Ma alkaloids olekanitsidwa ndi Fructus Aurantii ndi Lycium lalanje amathanso kulimbitsa kwakanthawi kukakamira kwa minofu yosalala, makamaka ikathandizidwa ndi pituitrin.

4. Antithrombotic: In vitro test of 0.1g/ml Fructus Aurantii aqua decoction inawonetsa antithrombotic kwenikweni.

5. Anti-allergenic reaction: 100mg / kg static pulse jekeseni wa Fructus Aurantii Aurantii wothira madzi amatha kulepheretsa khungu lachiwopsezo (PCA) mu makoswe, ndipo 50μg / ml ikhoza kuletsa kumasulidwa kwa histamine kuchokera ku makoswe a m'mimba.

6. Zotsatira zina: Citrus plant mycin imatha kuchepetsa cholestatin mu seramu ndi chiwindi cha makoswe omwe amadyetsedwa ndi zakudya zokhala ndi cholesterol. Mowa Tingafinye Fructus Aurantii anali ndi inhibitory zotsatira pa mycobacterium tuberculosis H37Rv mu m'galasi, ndi zoletsa ndende yake anali 1:1000. Decoction yake yamadzimadzi inalibe mphamvu pa bronchus ya nkhumba. Zanenedwa kuti madzi a zipatso za citrus amawonjezera kuwira kwa yisiti ndipo samachepetsa ntchito yake akaphika, kotero si gawo la enzymatic. Njira yaikulu yogwiritsira ntchito madzi a malalanje pachipatala ndi yakuti imakhala ndi vitamini C wochuluka ndipo imakhala ndi mavitamini A ndi B ochuluka. Peel ilibe vitamini C koma ili ndi vitamini A wochuluka. Imamva kuwawa ndipo imatha kulimbikitsa m'mimba. Ana monga kutenga ambiri peels angayambitse poizoni (m'mimba ululu, kukokana).

Zolemba: http://www.a-hospital.com

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