Kuyambitsa kwa Citrus Aurantium

Citrus Aurantium, chomera cha banja la rutaceae, chimapezeka kwambiri ku China. Citrus aurantium ndi dzina lachikhalidwe la Chitchaina la laimu. Mu mankhwala achikhalidwe aku China, citrus aurantium ndi chomera chachikhalidwe chomwe chimagwiritsidwa ntchito makamaka kuwonjezera chilakolako cha chakudya ndikulamulira qi (mphamvu). Ku Italy, citrus aurantium yakhalanso mankhwala achikhalidwe kuyambira m'zaka za zana la 16, omwe amagwiritsidwa ntchito pochiza malungo monga malungo komanso ngati mankhwala opha tizilombo toyambitsa matenda. Kafukufuku waposachedwapa wasonyeza kuti citrus aurantium imatha kulowa m'malo mwa ephedra pochiza kunenepa kwambiri popanda zotsatirapo zoyipa za mtima.

Zomwe zimagwira ntchito bwino mu citrus aurantium ndi hesperidin, neohesperidin, nobiletin, auranetin, aurantiamarin, nuringin, synephrine, limonin.

Chogwiritsira ntchito

hesperidin, neohesperidin, nobiletin, D-limonene, auranetin, aurantiamarin, citrin, synephrine, limonin

Katundu weniweni

Kusungunuka kwa kristalo, malo osungunuka 184-1850C, kusungunuka kwa carbonate 151-152, kusungunuka mosavuta m'madzi. Bitartrate, malo osungunuka 188-189, kusungunuka m'madzi, kovuta kusungunuka mu ethanol, pafupifupi osasungunuka mu chloroform, ether. Hydrochloride, kristalo wopanda mtundu (ethanol-ethyl ether), malo osungunuka 166-167. Kusinthika kwa racemization kumakhala kosavuta kuchitika pakulekanitsa kwa chromatography kwa ma resins amphamvu a asidi ndi base ion exchange.

Zotsatira za mankhwala
1. Zotsatira pa chiberekero: Fructus Aurantii ndi Fructus Aurantii Fructus Decoction kuchokera kumadera atatu osiyanasiyana obereketsa (Sichuan, Jiangxi, ndi Hunan) inawonetsa mphamvu yoletsa chiberekero mu vitro ya mbewa (zokhala ndi pakati ndi zopanda pakati); Chiberekero cha kalulu chinayamba kugwedezeka mu vitro komanso mu vitro (zokhala ndi pakati komanso zopanda pakati). Fistula ya uterine ya kalulu inatsimikiziranso kuti imapangitsa kuti chiberekero chikhale cholimba, kupsinjika kwakukulu, komanso ngakhale kugwedezeka kwa tetanic. Fructus Aurantii tincture ndi Fructus Aurantii fluid extract zimathanso kuyambitsa chiberekero cha kalulu (mu vitro ndi mu vitro). Chiberekero cha mbewa (mu vitro) chinaletsedwa. Mankhwala a alkaloid omwe adachotsedwa ku Fructus Aurantii ndi Lycium orange nawonso anali ndi mphamvu yoletsa chiberekero cha kalulu mu vitro, makamaka pa minofu ya uterine yomwe imayambitsidwa ndi pituitrin. Gawo la alkaloid lomwe linachotsedwa linali ndi mphamvu yoletsa chiberekero cha kalulu mu vitro, ndipo mphamvu yotsitsimula ya chiberekero inali yowonekera bwino pambuyo pa kusokonezeka kwa hypophysial. Cirantin, yotengedwa kuchokera ku Fructus Aurantii Fructus Peel, imaletsa ntchito ya hyaluronate kuzungulira dzira, zomwe zitha kukhala zokhudzana ndi mphamvu yake yoletsa kubereka (kuletsa umuna).

2. Zotsatira pa matumbo: Fructus Aurantii ndi Fructus Aurantii ochokera m'malo atatu osiyanasiyana adaletsa matumbo mwa mbewa ndi akalulu; Machubu ambiri a m'matumbo mwa akalulu adaletsedwa, koma ochepa sanasinthe. Fructus Aurantii ndi madzi ake otulutsa adaletsa machubu a m'matumbo a mbewa (in vitro) ndi akalulu (in vitro). Kuchuluka kwambiri (1:1000) kudaletsa matumbo ang'onoang'ono a akalulu ndi nkhumba za Guinea zomwe zidapatukana ndipo kudaletsa zotsatira za acetylcholine ndi histamine. Kuchuluka kochepa (1:10 000), pambuyo pa nthawi yochepa yoletsa, kumatha kuwonetsa mphamvu yoyambitsa, kukula kwake kudawonjezeka, komanso kuchuluka kwa nthawi kumawonjezeka. Mu agalu ogonekedwa, kupezeka kwa matumbo kudalepheretsedwa mwachiwonekere ndi decoctions. Koma kwa agalu omwe ali ndi gastroenterostomy, imakhala ndi mphamvu inayake yoyambitsa, yomwe ingapangitse kuyenda kwa m'mimba ndi kamvekedwe kake kukhala kolimba.

3. Zotsatira pa mtima ndi mitsempha yamagazi: kusinthasintha pang'ono kwa mpweya komanso kuletsa kwambiri mtima wa chule mu vitro. Fructus Aurantii ndi Fructus Aurantii Aurantii madzi otsekemera, Fructus Aurantii tincture, ndi madzi otulutsa ndi ofanana. Fructus Aurantii decoction kapena mowa wothira m'mitsempha ukhoza kubweretsa kupanikizika kwakukulu. Fructus Aurantii ndi Fructus Aurantii Fructus ochokera m'malo atatu osiyanasiyana adatsimikiziridwa kuti ali ndi zotsatira zochepa za vasoconstriction chifukwa cha kufalikira kwa achule m'mitsempha ya thupi lonse. Mwa agalu ogonekedwa, panali kuthamanga kwakukulu komanso kofulumira kwa kuthamanga kwa magazi. Panalibe kupsinjika kwa kupuma kapena kutsika kwa magazi komwe kumachitika chifukwa cha epinephrine, ndipo panalibe kuwonjezeka koonekeratu kwa kugunda kwa mtima.

Njira yowonjezera kuthamanga kwa magazi ikugwirizana ndi zinthu zotsatirazi:

3.1. Kusonkhezera kwa ma α receptors, zomwe zimayambitsa vasoconstriction m'ziwalo zina (phenylzoline imatha kusintha kukwera kwa kuthamanga kwa magazi kukhala antihypertensive reaction).

3.2. Kuwonjezeka kwa kufupika kwa mtima ndi kuchuluka kwa mphamvu ya mtima (kutuluka kwa mtima wa nkhumba ya Guinea yokha komanso kukonzekera kwa mtima ndi mapapo). Pambuyo pa reserpine, mphamvu yowonjezera mphamvu ya Fructus aurantii aurantii inali yofunika kwambiri. Inawonjezera kwambiri kuyenda kwa mitsempha ya mtima (289.4% inawonjezera kuyenda kwa mitsempha ya mtima ndi bubble flowmeter) ndikuwonjezera kuyenda kwa magazi muubongo ndi impso ndi 86.4% ndi 64.5% pa avareji, zomwe zinali zosiyana kwambiri ndi norepinephrine. Panali kuchepa kwa kuyenda kwa magazi kwa femoral ndi kuwonjezeka pang'ono koma kochepa kwa kugwiritsa ntchito mpweya wa mtima, zomwe sizinagwirizane ndi kuwonjezeka kwakukulu kwa kuyenda kwa mtima. Mu mayeso a ECG mwa agalu ndi nkhumba za Guinea, arrhythmia (ventricular tachycardia kapena atrioventricular block) yomwe imayambitsidwa ndi mlingo waukulu wa aurantii aurantii sinali yoopsa. Kutengera ndi makhalidwe omwe ali pamwambapa, akuti ndi yothandiza pochiza kugwedezeka kwa mtima. Ma alkaloid ochotsedwa ku Fructus Aurantii ndi Lycium orange amathanso kuwonjezera kwakanthawi kupsinjika kwa minofu yosalala ya mitsempha, makamaka akalandira chithandizo ndi pituitrin.

4. Kuchepetsa Kutsekeka kwa Magazi: Kuyesedwa kwa 0.1g/ml kwa Fructus Aurantii aqua decoction mu vitro kunawonetsa mphamvu yodziwikiratu yoletsa kutsekeka kwa magazi.

5. Kuthana ndi ziwengo: 100mg/kg jakisoni wa madzi otchedwa Fructus Aurantii Aurantii extract amatha kuletsa ziwengo za passive skin allergy (PCA) mwa makoswe, ndipo 50μg/ml imatha kuletsa kutulutsidwa kwa histamine kuchokera ku maselo a m'mimba a makoswe.

6. Zotsatira Zina: Mycin ya chomera cha citrus imatha kuchepetsa kuchuluka kwa cholestatin mu seramu ndi chiwindi cha makoswe omwe amadyetsedwa ndi zakudya zokhala ndi cholesterol. Chotsitsa cha mowa cha Fructus Aurantii chinali ndi mphamvu yoletsa mycobacterium tuberculosis H37Rv mu vitro, ndipo kuchuluka kwake koletsa kunali 1:1000. Madzi ake amadzi sanakhudze chifuwa cha nkhumba ya Guinea. Zanenedwa kuti madzi a zipatso za citrus amawonjezera kuchuluka kwa yisiti ndipo samachepetsa ntchito yake akawiritsa, kotero si gawo la enzyme. Kugwiritsa ntchito kwakukulu kwa madzi a lalanje m'chipatala ndikuti ali ndi vitamini C wambiri ndipo ali ndi mavitamini A ndi B ambiri. Khungu lake silili ndi vitamini C koma lili ndi vitamini A wambiri. Limakoma owawa ndipo limatha kulimbitsa m'mimba. Ana monga kutenga makhungu ambiri amatha kuyambitsa poizoni (kupweteka m'mimba, kupweteka m'mimba).

Buku Lothandizira: http://www.a-hospital.com

KwaChotsitsa cha Citrus Aurantium, chonde titumizireni uthenga. Tikukudikirani kuno nthawi iliyonse!!!