Shikimic Acid ndi chiyani?

Asidi Shikimic (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) ndi mwachilengedwe popanga organic pawiri kuti ndi yofunika wapakatikati biosynthesis wa lignin, onunkhira amino zidulo (phenylalanine, tyrosine ndi tryptophan), ndi ambiri. alkaloids zomera ndi tizilombo tating'onoting'ono.

Asidi ya Shikimic imagwiritsidwa ntchito ngati poyambira pakupanga mafakitale a mankhwala oletsa tizilombo toyambitsa matenda oseltamivir (mankhwala odana ndi H5N1 fuluwenza omwe amagwiritsidwa ntchito pochiza ndi kupewa mitundu yonse yodziwika ya ma virus a chimfine). Kaphatikizidwe ka (-) -zeylenone yochokera ku Shikimic Acid yanenedwa kuti imagwiritsidwa ntchito kwambiri ngati wothandizira khansa ya chemotherapy. Deta zilipo pa synthesis wa monopalmitoyloxy Shikimic Acid, amene ali anticoagulant ntchito ndipo amatha kuchepetsa magazi coagulability pamene kutumikiridwa intramuscularly. Gulu lofufuza ku China lidapanga chochokera ku Shikimic Acid, triacetyl Shikimic Acid, yomwe imawonetsa anticoagulant ndi antithrombotic.

Kuphatikiza apo, zotumphukira za Shikimic Acid zawonetsa chidwi chachikulu paulimi chifukwa ambiri aiwo amagwiritsidwa ntchito ngati mankhwala ophera udzu komanso antimicrobial agents chifukwa amatha kuletsa njira ya Shikimic Acid muzomera ndi mabakiteriya popanda kuwononga nyama zoyamwitsa.

Chifukwa chake, Asidi ya Shikimic imatha kugwiritsidwa ntchito ngati chotsutsana ndi kaphatikizidwe ka organic mu sayansi yoyambira ndi ntchito zamankhwala mu organic chemistry ndi mankhwala, makamaka pokonzekera mankhwala osiyanasiyana.

Monga chinthu chofunika kwambiri cha mankhwala, shikimic acid ingagwiritsidwe ntchito pochiza matenda ambiri:

1. Antibacterial ndi antitumor

Mu 1987, akatswiri a ku Japan adapeza kuti analogi ya glyoxalase I inhibitor yopangidwa ndi methyl anthranilate imakhala ndi zotsatira zodziwikiratu pa mzere wa maselo a Hela ndi Escheri ascites carcinoma, imatha kutalikitsa nthawi yopulumuka ya mbewa zomwe zimayambitsidwa ndi khansa ya m'magazi L1210, ndipo kawopsedwe ake ndi ochepa. zotsatira zake zolepheretsa makamaka zokhudzana ndi sulfure hydride reaction. 1988, akatswiri Chinese ndi Mu 1988, akatswiri Chinese apanga shikimic asidi otumphukira ndipo anatsimikizira kuti pawiri ali ndi zotsatira za inhibiting khansa maselo L1210 mu m'galasi.

2. Anti-thrombosis

Zotsatira za shikimic acid ndi zotumphukira zake pamtima pamtima zimawonetsedwa mu gawo la anti-thrombosis komanso kuletsa kuphatikizika kwa mapulateleti. Kafukufuku akuwonetsa kuti: asidi a shikimic ali ndi mphamvu yoletsa kuphatikizika kwa mapulateleti adenosine diphosphate-induced middle of the cerebral artery embolism model makoswe; jakisoni wa shikimic acid wolowa m'mitsempha komanso mu mnofu amatha kupangitsa kuti magazi aziundana a mbewa azitalikira.

3.Anti-cerebral ischemia

Asidi Shikimic ndi zotumphukira zake ndi zotsatira za kusintha ubongo ischemia, makamaka kuchepetsa voliyumu infarction ubongo pambuyo focal cerebral ischemia mu makoswe, kuchepetsa minyewa ntchito mphambu, kuchepetsa mlingo wa edema ubongo, kuonjezera otaya magazi mu ischemic dera. ndi zizindikiro zina. Kafukufuku wina wasonyeza kuti zotumphukira zake zimatha kuchepetsa kuchuluka kwa erythrocyte aggregation ndikuletsa kuphatikizika kwa mapulateleti pambuyo pa cerebral ischemia, motero kumathandizira kufalikira kwaubongo.