Kodi Shikimic Acid ndi chiyani?

Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) ndi mankhwala achilengedwe omwe amapezeka mwachilengedwe omwe ndi ofunikira kwambiri pakupanga lignin, amino acids onunkhira (phenylalanine, tyrosine ndi tryptophan), komanso ma alkaloids ambiri a zomera ndi tizilombo toyambitsa matenda.

Shikimic acid nthawi zambiri imagwiritsidwa ntchito ngati chinthu choyambira popanga mankhwala oletsa mavairasi otchedwa oseltamivir (mankhwala oletsa mavairasi a H5N1 omwe amagwiritsidwa ntchito pochiza ndikuletsa mitundu yonse yodziwika ya mavairasi a chimfine). Kupangidwa kwa (-)-zeylenone kochokera ku Shikimic Acid kwanenedwa kuti kumagwiritsidwa ntchito kwambiri ngati mankhwala a khansa. Deta ilipo yokhudza kupanga monopalmitoyloxy Shikimic Acid, yomwe ili ndi mphamvu yoletsa magazi kuundana ndipo imatha kuchepetsa kuuma kwa magazi ikaperekedwa ndi intramuscularly. Gulu lofufuza la ku China linapanga Shikimic Acid derivative, triacetyl Shikimic Acid, yomwe imasonyeza mphamvu yoletsa magazi kuundana komanso yoletsa magazi kutuluka magazi.

Kuphatikiza apo, zinthu zochokera ku Shikimic Acid zasonyeza chidwi chachikulu pa ulimi chifukwa zambiri mwa izo zimagwiritsidwa ntchito ngati mankhwala ophera udzu komanso mankhwala opha tizilombo toyambitsa matenda chifukwa zimatha kutseka njira ya Shikimic Acid mu zomera ndi mabakiteriya popanda kuwononga nyama zoyamwitsa.

Motero, Shikimic Acid ingagwiritsidwe ntchito ngati reactant popanga zinthu zachilengedwe mu sayansi yoyambira komanso ntchito zachipatala mu organic chemistry ndi mankhwala, makamaka pokonzekera mankhwala osiyanasiyana.

Monga mankhwala ofunikira, shikimic acid ingagwiritsidwe ntchito pochiza matenda ambiri:

1. Mankhwala oletsa mabakiteriya komanso oletsa chotupa

Mu 1987, akatswiri aku Japan adapeza kuti analog ya glyoxalase I inhibitor yopangidwa ndi methyl anthranilate ili ndi mphamvu yoletsa yodziwikiratu pa mzere wa maselo a Hela ndi Escheri ascites carcinoma, imatha kutalikitsa nthawi yopulumuka ya mbewa zomwe zalandira katemera wa leukemia cell L1210, ndipo poizoni wake ndi wochepa, mphamvu yake yoletsa imakhudzana kwambiri ndi sulfure hydride reaction. 1988, akatswiri aku China adachita Mu 1988, akatswiri aku China adapanga chochokera ku shikimic acid ndipo adatsimikizira kuti mankhwalawa ali ndi mphamvu yoletsa maselo a leukemia L1210 mu vitro.

2. Kuletsa kutsekeka kwa magazi m'mitsempha

Mphamvu ya shikimic acid ndi zinthu zochokera m'thupi pa dongosolo la mtima ikuwonetsedwa mu ntchito yake yoletsa thrombosis ndi kuletsa kusonkhana kwa ma platelet. Kafukufuku akusonyeza kuti: shikimic acid imaletsa kwambiri kuchuluka kwa kusonkhana kwa ma platelet a makoswe omwe amatsatira chitsanzo cha adenosine diphosphate-induced middle cerebral artery embolism; jakisoni wa shikimic acid kudzera m'mitsempha ndi m'mitsempha kungapangitse kuti nthawi yotseka magazi ya mbewa ikhale yayitali.

3. Kulephera kwa ubongo kugwira ntchito bwino

Shikimic acid ndi zinthu zochokera mkati mwake zimathandiza kwambiri kuti ubongo ukhale ndi ischemia, makamaka pochepetsa kuchuluka kwa matenda a ubongo pambuyo pa ischemia ya ubongo m'makoswe, kuchepetsa kuchuluka kwa ntchito ya mitsempha, kuchepetsa kuchuluka kwa kutupa kwa ubongo, kuwonjezera kuyenda kwa magazi mu ubongo m'dera la ischemic ndi zizindikiro zina. Kafukufuku wina wasonyeza kuti zinthu zochokera mkati mwake zimatha kuchepetsa kuchuluka kwa erythrocyte aggregation ndikuletsa kusonkhana kwa ma platelet pambuyo pa ischemia ya ubongo, motero zimathandiza kuti ubongo ukhale ndi magazi ambiri.